2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE
- CAS No.
- 6564-72-3
- Chemical Name:
- 2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE
- Synonyms
- Voglibose int;benzylglucopyranose;Tetrabenzyl glucose;Voglibose Impurity 1;Voglibose TBG IMpurity;Voglibose TBG impurities;Voglibose alpha-TBG Impurity;2,3,4,6-tetra-o-benzyl-d-glucose;6-Tetra-O-benzyl-D-glucopyranose;2,3,4,6-Tetra-o-benzyl-D-glucopyransoe
- CBNumber:
- CB0234449
- Molecular Formula:
- C34H36O6
- Molecular Weight:
- 540.66
- MDL Number:
- MFCD00066004
- MOL File:
- 6564-72-3.mol
Melting point | 151-156 °C |
---|---|
Boiling point | 672.4±55.0 °C(Predicted) |
Density | 1.22 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
pka | 11.87±0.70(Predicted) |
Water Solubility | Soluble in CHCl3. Insoluble in water. |
LogP | 5.9 at 20℃ and pH6.5 |
CAS DataBase Reference | 6564-72-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | H31595 | 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranose, 98% | 6564-72-3 | 1g | $55.65 | 2024-03-01 | Buy |
Alfa Aesar | H31595 | 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranose, 98% | 6564-72-3 | 5g | $180.65 | 2024-03-01 | Buy |
TRC | P992030 | 2,3,4,6-Tetra-O-benzyl-α-D-glucopyranose | 6564-72-3 | 100mg | $60 | 2021-12-16 | Buy |
TRC | P992030 | 2,3,4,6-Tetra-O-benzyl-α-D-glucopyranose | 6564-72-3 | 500mg | $90 | 2021-12-16 | Buy |
Usbiological | 294905 | 2,3,4,6-Tetra-O-benzoyl-D-glucopyranose | 6564-72-3 | 100mg | $375 | 2021-12-16 | Buy |
2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE Chemical Properties,Uses,Production
Description
2,3,4,6-Tetra-O-benzyl-D-glucopyranose is a selectively protected intermediate, where the anomeric 1-O-hydroxyl group is free. This hemiacetal has been used successfully as an intermediate for glucosylation couplings, where it was converted into 2,3,4,6-tetra-O-benzyl-D-glucopyranose trichloroacetimidate using trichloroacetonitrile in the presence of a base such as potassium carbonate and DBU.
Importantly, this imidate donor with no neighbouring participating groups is commonly used for the selective formation of glucosides. 2,3,4,6-tetra-O-benzyl-D-glucopyranose can also be oxidized to the lactone, or reduced to give the open chain form.
Additionally, 2,3,4,6-tetra-O-benzyl-D-glucopyranose can be used for the preparation of glucono-1,5-lactone hydrazine, which was used, in-turn, to form a glucosylidene-spirocyclopropane.
Uses
It is the intermediate of Voglibose/Dapagliflozin. An important D-glucopyranose derivative for glucosylations and other reactions 1,2; Preparation of the α-glucopyranosyl chloride, synthesis of 1-C-α-D-glucopyranose derivatives.
Synthesis
Octa-O-Dissolves benzyl sucrose or octa-O-allyl sucrose in an organic solvent with the addition of hydrochloric acid without prior chromatographic purification, allows it to react for 20-60 minutes at temperatures of 50-60 °C. and then cleans the end product formed by crystallization. (ethanol, isopropanol, acetone, benzene, toluene or mixtures thereof can be used as solvents).
2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12465 | 58 |
Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15544 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16223 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 15093356674; | sales@coreychem.com | China | 29914 | 58 |
Jinan Samuel Pharmaceutical CO., Ltd | 0531-88821801 15192360884 | 605818151@qq.com | CHINA | 124 | 58 |
Related articles
- 2,3,4, 6-Tetra-o-benzyl-α-D-Glucopyranose method for preparing partial benzylated aldopyranose
- It is capable of synthesising some of the benzylated aldopyranose. And the method has good availability and low cost.
- Nov 17,2023
View Lastest Price from 2,3,4,6-TETRA-O-BENZYL-ALPHA-D-GLUCOPYRANOSE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-22 | 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
|
US $50.00-10.00 / kg | 1kg | 99% | 20MT | Hebei Duling International Trade Co. LTD | ||
2023-08-24 | 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2021-11-02 | 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
|
US $250.00 / KG | 1KG | 99% | 100KGS | Baoji Guokang Healthchem co.,ltd |
- 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
- US $50.00-10.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
- 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- 2,3,4,6-TETRA-O-BENZYL-D-GLUCOPYRANOSE
6564-72-3
- US $250.00 / KG
- 99%
- Baoji Guokang Healthchem co.,ltd
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