Vemakalant
- CAS No.
- 794466-70-9
- Chemical Name:
- Vemakalant
- Synonyms
- CS-419;Vemakalant;Vernakalant;Vemakalant USP/EP/BP;Vernakalant (RSD-1235);VERNAKALANT;RSD1235;RSD 1235;RSD-1235;Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer);(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol;(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
- CBNumber:
- CB02498847
- Molecular Formula:
- C20H31NO4
- Molecular Weight:
- 349.46
- MDL Number:
- MFCD16038313
- MOL File:
- 794466-70-9.mol
- MSDS File:
- SDS
| Boiling point | 479.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO |
| form | Powder |
| pka | 14.79±0.20(Predicted) |
| FDA UNII | 9G468C8B13 |
| ATC code | C01BG11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Vemakalant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0014187 | VERNAKALANT 95.00% | 794466-70-9 | 5MG | $495.37 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014187 | VERNAKALANT 95.00% | 794466-70-9 | 10MG | $649.95 | 2021-12-16 | Buy |
| Crysdot | CD31000781 | Vernakalant 98+% | 794466-70-9 | 50mg | $1124 | 2021-12-16 | Buy |
| Crysdot | CD31000781 | Vernakalant 98+% | 794466-70-9 | 10mg | $375 | 2021-12-16 | Buy |
Vemakalant Chemical Properties,Uses,Production
Pharmacological action
Venakaran works by blocking peak sodium currents by blocking overdrive-activated delayed rectifier currents (IKur). IKur, encoded by the Kv1.5 channel protein, is abundantly expressed in atrial myocytes, is the main current mediating atrial repolarization in humans, and is activated during atrial fibrillation. Venakalan inhibition of IKur can prolong the action potential duration of the atrium, thereby prolonging the atrial effective refractory period and slowing down atrial conduction, so as to shorten the time of atrial fibrillation and quickly achieve the effect of atrial fibrillation conversion.
Description
Vernakalant is a potassium channel blocker that was approved in Europe in 2010 for treatment of atrial fibrillation (AF), a condition of cardiac arrhythmia in which the atria of the heart beat irregularly due to changes in cardiac ion channel function and distribution. Vernakalant has activity for cardiac Na+ and K+ channels and also for the atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized in animal models to assess efficacy, atrial selectivity, and reduction in side effects.
Originator
Cardiome Pharma Corp. (Canada)
Definition
ChEBI: Vernakalant is an alcohol and a member of phenols.
brand name
Brinavess
Vemakalant Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Vemakalant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Vemakalant
794466-70-9
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | Vernakalant
794466-70-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Vernakalant
794466-70-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Vemakalant
794466-70-9
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Vernakalant
794466-70-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Vernakalant
794466-70-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd