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Conivaptan hydrochloride

Conivaptan hydrochloride Structure
Conivaptan hydrochloride structure
CAS No.
168626-94-6
Chemical Name:
Conivaptan hydrochloride
Synonyms
Vaprisol;Conivaptan HCI;Conivaptan HCl;Unii-75L57R6X36;Conivaptan HCl (YM 087);Conivaptan hydrochkoride;Conivaptan hydrochloride;Conivaptan hydrochloride [usan];Conivaptan hydrochloride, >=99%;Conivaptan hydrochloride USP/EP/BP
CBNumber:
CB81246922
Molecular Formula:
C32H26N4O2.HCl
Molecular Weight:
535.04
MDL Number:
MFCD00945712
MOL File:
168626-94-6.mol
MSDS File:
SDS
Last updated:2023-08-14 13:33:12
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Conivaptan hydrochloride Properties

Melting point >250°
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
InChIKey BTYHAFSDANBVMJ-UHFFFAOYSA-N
SMILES C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl
FDA UNII 75L57R6X36

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P501-P270-P264-P301+P312+P330

Conivaptan hydrochloride price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23728 Conivaptan (hydrochloride) ≥95% 168626-94-6 5mg $68 2024-03-01 Buy
Cayman Chemical 23728 Conivaptan (hydrochloride) ≥95% 168626-94-6 10mg $121 2024-03-01 Buy
Cayman Chemical 23728 Conivaptan (hydrochloride) ≥95% 168626-94-6 25mg $268 2024-03-01 Buy
Cayman Chemical 23728 Conivaptan (hydrochloride) ≥95% 168626-94-6 50mg $469 2024-03-01 Buy
Tocris 6830 Conivaptanhydrochloride ≥98%(HPLC) 168626-94-6 50 $214 2021-12-16 Buy
Product number Packaging Price Buy
23728 5mg $68 Buy
23728 10mg $121 Buy
23728 25mg $268 Buy
23728 50mg $469 Buy
6830 50 $214 Buy

Conivaptan hydrochloride Chemical Properties,Uses,Production

Description

Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbalance of sodium and water, particularly congestive heart failure. To restore homeostasis, antagonism of vasopressin receptors is a practical solution. As such, conivaptan has been developed and launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive, reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2 receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum sodium concentration and reducing total body volume. Currently, the drug is approved for the management of refractory hyponatremia and potentially lifethreatening sodium and water imbalance, but it has shown promise as a potential treatment option for other diseases, such as congestive heart failure, syndrome of antidiuretic hormone, diabetes insipidus, and liver cirrhosis.

Description

Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively). It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.

Chemical Properties

White to Off-White Solid

Originator

Yamanouchi (Japan)

Uses

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

Uses

Used in treatment of congestive heart failure.

Definition

ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau ed by syndrome of inappropriate antidiuretic hormone (SIADH).

brand name

Vaprisol (Astellas).

storage

Desiccate at RT

Conivaptan hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Conivaptan hydrochloride Suppliers

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106 sales@trywchem.com China 129 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
58
shandong perfect biotechnology co.ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
career henan chemical co 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from Conivaptan hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Conivaptan HCl pictures 2024-03-12 Conivaptan HCl
168626-94-6
 US $0.00 / g 1g 98% HPLC 100kg shandong perfect biotechnology co.ltd
Conivaptan hydrochloride pictures 2022-09-30 Conivaptan hydrochloride
168626-94-6
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Conivaptan hydrochloride USP/EP/BP pictures 2021-08-13 Conivaptan hydrochloride USP/EP/BP
168626-94-6
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Conivaptan HCl pictures
  • Conivaptan HCl
    168626-94-6
  • US $0.00 / g
  • 98% HPLC
  • shandong perfect biotechnology co.ltd

Conivaptan hydrochloride Spectrum

Conivaptan hydrochloride(168626-94-6)1HNMR

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(1,1'-Biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-, monohydrochloride Conivaptan HCl Conivaptan hydrochloride [usan] Unii-75L57R6X36 Vaprisol Conivaptan hydrochkoride N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride Conivaptan HCI N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide, hydrochloride (1:1) [1,1'-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,hydrochloride Conivaptan hydrochloride, >=99% Conivaptan hydrochloride N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamid N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride N-(4-(2-methyl-3,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride 1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1) Conivaptan hydrochloride USP/EP/BP Conivaptan HCl (YM 087) Conivaptan HydrochlorideQ: What is Conivaptan Hydrochloride Q: What is the CAS Number of Conivaptan Hydrochloride Q: What is the storage condition of Conivaptan Hydrochloride Q: What are the applications of Conivaptan Hydrochloride Vaprisol, Conivaptan hydrochloride N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride 168626-94-6 C32H26N4O2HCl C32H27ClN4O2 Inhibitors Aromatics Intermediates & Fine Chemicals Pharmaceuticals