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5-R-Rivaroxaban

5-R-Rivaroxaban structure

CAS No.: 865479-71-6

Chemical Name:: 5-R-Rivaroxaban

Synonyms: R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;5-R-Rivaroxaban;ent-Rivaroxaban;Rivaroxyban R-isomer;Rivaroxaban R-Isomer;XARELTO; BAY 59-7939;R-Rivaroxaban Impurity;R-Isomer of Rivaroxaban

CBNumber:: CB02624033

Molecular Formula:: C19H18ClN3O5S

Molecular Weight:: 435.88

MDL Number:: MFCD17171369

MOL File:: 865479-71-6.mol

MSDS File:: SDS

Last updated:2024-04-25 17:59:01

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5-R-Rivaroxaban Properties

Melting point	>227°C (dec.)
Boiling point	732.6±60.0 °C(Predicted)
Density	1.460
storage temp.	Refrigerator
solubility	Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol
form	Solid
pka	13.36±0.46(Predicted)
color	White to Off-White
FDA UNII	RJP4GEG36M

5-R-Rivaroxaban price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	R538005	ent-Rivaroxaban	865479-71-6	25mg	$180	2021-12-16	Buy
Usbiological	448268	ent-Rivaroxaban	865479-71-6	10mg	$368	2021-12-16	Buy
ChemScene	CS-0730	5-R-Rivaroxaban 99.72%	865479-71-6	50mg	$370	2021-12-16	Buy
ApexBio Technology	A3126	5-R-Rivaroxaban	865479-71-6	50mg	$370	2021-12-16	Buy
Medical Isotopes, Inc.	98910	ent-Rivaroxaban	865479-71-6	1mg	$385	2021-12-16	Buy

Product number	Packaging	Price	Buy
R538005	25mg	$180	Buy
448268	10mg	$368	Buy
CS-0730	50mg	$370	Buy
A3126	50mg	$370	Buy
98910	1mg	$385	Buy

5-R-Rivaroxaban Chemical Properties,Uses,Production

Uses

ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Biological Activity

5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].

References

[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.

5-R-Rivaroxaban Preparation Products And Raw materials

Raw materials

Preparation Products

5-R-Rivaroxaban Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3149	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
ANHUI WITOP BIOTECH CO., LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Huarong Pharm Co., Ltd.	58

View Lastest Price from 5-R-Rivaroxaban manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-25	5-R-Rivaroxaban 865479-71-6	US $8.00-2.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

5-R-Rivaroxaban
865479-71-6
US $8.00-2.00 / kg
99%
Henan Fengda Chemical Co., Ltd

5-R-Rivaroxaban Spectrum

5-R-Rivaroxaban(865479-71-6)¹HNMR

865479-71-6(5-R-Rivaroxaban)Related Search:

4-(3-nitrophenyl)-3-Morpholinone 3-Morpholinone, 4-phenyl- 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Palbociclib Impurity 21 3'-N-DesMethyl-3'-N-tosyl AzithroMycin

[[p-(2-methoxyethyl)phenoxy]methyl]oxirane 1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Rivaroxaban (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide

Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 5-Methyl-2-thiophenecarboxylic acid 5-chloro-N-(4-((S)-5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-oxo-2-((((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)amino)ethoxy)ethyl)thiophene-2-carboxamide

3,5-dichlorothiophene-2-carboxylic acid Rivaroxaban Impurity H 1H-Benzotriazole, 1-hydroxy-, sodium salt

1of4

5-R-Rivaroxaban 5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide R-Rivaroxaban (R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide ent-Rivaroxaban (R)-Rivaroxaban, ent-Rivaroxaban Rivaroxyban R-isomer R-ENANTIOMER OF RIVAROXABAN Rivaroxaban Impurities364 Rivaroxaban EP Impurity A 5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide Rivaroxaban R-Isomer Impurity Rivaroxaban R-Isomer Rivaroxaban Impurity 6(Rivaroxaban R-Isomer) (S)-4-(4-(5-(((2-methyl-4-oxopentan-2-yl)amino)methyl)-2- oxooxazolidin-3-yl)phenyl)morpholin-3-one XARELTO; BAY 59-7939 Rivaroxaban impurity H: 5-R Rivaroxaban Rivaroxaban A 2-Thiophenecarboxamide, 5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- Rivaroxaban impurity 7/5-R-Rivaroxaban/ent-Rivaroxaban/5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide Rivaroxaban-6 R-Rivaroxaban Impurity Rivaroxaban R-Isomer (ent-Rivaroxaban) Rivaroxaban EP Impurity A/Rivaroxaban R-isomer Impurity Rivaroxaban Enantiomer (R-Isomer) R-Isomer of Rivaroxaban 865479-71-6