EG00229
- CAS No.
- 1210945-69-9
- Chemical Name:
- EG00229
- Synonyms
- CS-1273;EG00229;EG00229 TFA;EG00229,EG-00229;EG 00229 Trifluoroacetate;EG 00229 (trifluoroacetate salt)
- CBNumber:
- CB02627791
- Molecular Formula:
- C19H20F3N7O7S3
- Molecular Weight:
- 611.59
- MDL Number:
- MOL File:
- 1210945-69-9.mol
- MSDS File:
- SDS
EG00229 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3408 | EG00229 trifluoroacetate ≥98% (HPLC) | 1210945-69-9 | 5MG | $162 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3408 | EG00229 trifluoroacetate ≥98% (HPLC) | 1210945-69-9 | 25MG | $519 | 2024-03-01 | Buy |
| Tocris | 6986 | EG00229trifluoroacetate ≥98%(HPLC) | 1210945-69-9 | 10 | $265 | 2021-12-16 | Buy |
| TRC | E440000 | EG00229TrifluoroaceticAcidSalt | 1210945-69-9 | 50mg | $1000 | 2021-12-16 | Buy |
| TRC | E440000 | EG00229TrifluoroaceticAcidSalt | 1210945-69-9 | 25mg | $525 | 2021-12-16 | Buy |
EG00229 Chemical Properties,Uses,Production
Uses
EG 00229 Trifluoroacetic Acid Salt is an antagonist of the VEGFA receptor neuropilin (NRP1). This antagonism can result in the attenuation of prostate carcinoma cell proliferation.
Biological Activity
eg00229 is a small molecule inhibitor of neuropilin-1(nrp1) with an ic50 of 3μm [1].eg00229 has been reported to inhibit vegf-a binding to pae/nrp1 in the nrp1and bt-vegf-a binding to purified nrp1 b1 domain in a cell-free assay with an ic50 value of 8μm and 3μm, respectively. in addition, eg00229 has also shown the inhibition of vegf-a binding to vegfr2, vegfr1 and nrp1 in human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with an ic50 value of 23μm [1]. besides, eg00229 has been revealed to prevent tuftsin binding to the nrp1 which is at the cell surface. moreover, eg00229 has been noted to suppress the anti-inflammatory m2 shift in microglia induced by tuftsin and thus potently prevent tuftsin’s action [2].
storage
Store at -20°C
References
[1] jarvis a1, allerston ck, jia h, herzog b, garza-garcia a, winfield n, ellard k, aqil r, lynch r, chapman c, hartzoulakis b, nally j, stewart m, cheng l, menon m, tickner m, djordjevic s, driscoll pc, zachary i, selwood dl.small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor a (vegf-a) interaction. j med chem. 2010 mar 11;53(5):2215-26.
[2] nissen jc1, selwood dl, tsirka se. tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. j neurochem. 2013 nov;127(3):394-402.
EG00229 Preparation Products And Raw materials
Raw materials
Preparation Products
EG00229 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3420 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |