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ChemicalBook >> CAS DataBase List >>(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid Structure
(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid structure
CAS No.
98818-49-6
Chemical Name:
(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid
Synonyms
(2R,4R,5S)-2-benzyl-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilyloxy)-6-phenylhexanoic acid;(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid;Benzenehexanoic acid, δ-[[(1,1-dimethylethoxy)carbonyl]amino]-γ-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-(phenylmethyl)-, (αR,δS,γR)-
CBNumber:
CB02724577
Molecular Formula:
C30H45NO5Si
Molecular Weight:
527.78
MDL Number:
MOL File:
98818-49-6.mol
Last updated:2023-05-02 08:29:08
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(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid Properties

Boiling point 629.7±55.0 °C(Predicted)
Density 1.061±0.06 g/cm3(Predicted)
solubility Ethyl Acetate
form Foam
pka 4.45±0.10(Predicted)
color White

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D473365 (αR,δS,γR)-δ-[[(1,1-Dimethylethoxy)carbonyl]amino]-γ-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-(phenylmethyl)benzenehexanoicAcid 98818-49-6 25mg $140 2021-12-16 Buy
Medical Isotopes, Inc. 64542 (αR,ΔS,γR)-Δ-[[(1,1-Dimethylethoxy)carbonyl]amino]-γ-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-(phenylmethyl)benzenehexanoicAcid 98818-49-6 25mg $625 2021-12-16 Buy
Product number Packaging Price Buy
D473365 25mg $140 Buy
64542 25mg $625 Buy

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid Chemical Properties,Uses,Production

Uses

(αR,δS,γR)-δ-[[(1,1-Dimethylethoxy)carbonyl]amino]-γ-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-(phenylmethyl)benzenehexanoic Acid is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the major causative agent in Alzheimer disease (AD).

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid synthesis

98737-42-9
98818-49-6
Synthesis of (αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid from N-[(1S)-2-Phenyl-1-[(2R,4R)-tetrahydro-5-oxo-4-(phenylMethyl)-2-furanyl]ethyl] CarbaMic Acid 1,1-DiMethylethyl Ester

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid Preparation Products And Raw materials

Raw materials

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-hydroxy-α-(phenylMethyl)benzenehexanoic Acid N-[(1S)-2-Phenyl-1-[(2R,4R)-tetrahydro-5-oxo-4-(phenylMethyl)-2-furanyl]ethyl] CarbaMic Acid 1,1-DiMethylethyl Ester tert-Butyldimethylsilyl chloride

Preparation Products

(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Supplier Advantage
Chemsky（shanghai）International Co.,Ltd. 50
(αR,δS,γR)-δ-[[(1,1-DiMethylethoxy)carbonyl]aMino]-γ-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-α-(phenylMethyl)benzenehexanoic Acid (2R,4R,5S)-2-benzyl-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilyloxy)-6-phenylhexanoic acid Benzenehexanoic acid, δ-[[(1,1-dimethylethoxy)carbonyl]amino]-γ-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-(phenylmethyl)-, (αR,δS,γR)- 98818-49-6 C30H45NO5Si