Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>tert-Butyldimethylsilyl chloride

tert-Butyldimethylsilyl chloride

tert-Butyldimethylsilyl chloride Structure
tert-Butyldimethylsilyl chloride structure
CAS No.
18162-48-6
Chemical Name:
tert-Butyldimethylsilyl chloride
Synonyms
TBSCL;TBDMSCL;TERT-BUTYLCHLORODIMETHYLSILANE;T-BUTYLDIMETHYLSILYL CHLORIDE;TBDMSCI;TERT-BUTYLDIMETHYLCHLOROSILANE;tert-Butyldimethylsilyl;SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL-;TBDMCl;T-BUTYLDIMETHYLCHLOROSILANE
CBNumber:
CB3763003
Molecular Formula:
C6H15ClSi
Molecular Weight:
150.72
MOL File:
18162-48-6.mol
MSDS File:
SDS
Request For Quotation

tert-Butyldimethylsilyl chloride Properties

Melting point 86-89 °C (lit.)
Boiling point 125 °C (lit.)
Density 0.87 g/mL at 20 °C(lit.)
refractive index n20/D 1.46
Flash point 73 °F
storage temp. Store below +30°C.
solubility very sol nearly all common organic solvents such as THF, methylene chloride, and DMF.
form Liquid
color Clear colorless
Specific Gravity 1.225
Water Solubility Soluble in chloroform and ethyl acetate. Insoluble in water.
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
BRN 505999
InChIKey BCNZYOJHNLTNEZ-UHFFFAOYSA-N
CAS DataBase Reference 18162-48-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 550OPF5Z9F
NCI Dictionary of Cancer Terms BDCS
NIST Chemistry Reference Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA Substance Registry System Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS02,GHS05
Signal word  Danger
Hazard statements  H225-H304-H314-H336-H361d-H373-H302-H335-H351-H226-H228-H318-H361
Precautionary statements  P309-P240-P241-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P210-P261-P280-P301+P310-P305+P351+P338-P310-P260-P370+P378-P403+P235
Hazard Codes  C,F,T,Xn
Risk Statements  22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements  26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR  UN 2925 4.1/PG 2
WGK Germany  2
RTECS  VV2000000
F  10-21
Hazard Note  Flammable/Corrosive/Moisture Sensitive
TSCA  Yes
HazardClass  4.1
PackingGroup  III
HS Code  29310095
NFPA 704
2
3 0

tert-Butyldimethylsilyl chloride price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18642 tert-Butyldimethylchlorosilane for synthesis 18162-48-6 25g $153 2022-05-15 Buy
Sigma-Aldrich 8.18642 tert-Butyldimethylchlorosilane for synthesis 18162-48-6 100g $292 2022-05-15 Buy
Sigma-Aldrich 06735 tert-Butyldimethylsilyl chloride for GC derivatization, ≥99.0% (GC) 18162-48-6 10g $109 2022-05-15 Buy
TCI Chemical B0995 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) 18162-48-6 5g $24 2022-04-27 Buy
TCI Chemical B0995 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) 18162-48-6 25g $72 2022-04-27 Buy
Product number Packaging Price Buy
8.18642 25g $153 Buy
8.18642 100g $292 Buy
06735 10g $109 Buy
B0995 5g $24 Buy
B0995 25g $72 Buy

tert-Butyldimethylsilyl chloride Chemical Properties,Uses,Production

Chemical Properties

tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.

Uses

tert-Butyldimethylsilyl Chloride is a chemical used to protect alcohols during organic synthesis.

Uses

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

Uses

t-Butyldimethylchlorosilane is useful as an anion trapping reagent. For example, TBDMSCl was found to be an efficient trap of the lithio α-phenylthiocyclopropane anion.When dichlorothiophene was treated with 2 equiv of n-butyllithium followed by 2 equiv of TBDMSCl the di-TBDMS-thiophene was isolated. The lithium anions of primary (eq 1) and secondary (eq 2) nitriles were trapped with TBDMSCl to give C,N-disilyl- and Nsilylketenimines in excellent yields.
Silyl stannanes have been prepared by trapping tin anions with TBDMSCl or other silyl chlorides. Alkynes treated with silyl stannanes and catalytic tetrakis(triphenylphosphine)palladium(0) give cis-silyl stannylalkenes in good yields.

Preparation

tert-butyldimethylsilyl chloride (TBSCI, mp 86–89 °C) is expensive though it is readily prepared in high yield by the reaction of tert-butyllithium with dichlorodimethylsilane.

Definition

ChEBI: Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

Reactions

tert-Butyldimethylsilyl chloride reacts with alcohols in the presence of base to give tert-butyldimethylsilyl ethers:(Me3C)Me2SiCl + ROH → (Me3C)Me2SiOR + HCl
These silyl ethers hydrolyze much more slowly than the trimethylsilyl ethers.

Hazard

Moderately toxic.

Purification Methods

Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]

tert-Butyldimethylsilyl chloride Preparation Products And Raw materials

Raw materials

tert-Butyllithium Pentane Dichlorodimethylsilane

Preparation Products

beta-Methyl vinyl phosphate (MAP) (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 2-Chloro-4-nitrophenyl-alpha-L-fucopyranoside Calcipotriene Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester
2-CYANOPYRIDINE-4-CARBOXALDEHYDE 4-Mercaptophenylboronic acid Montelukast 4-(HYDROXYMETHYL)PICOLINITRILE 5-(AMINOMETHYL)-1-METHYLPYRROLIDIN-2-ONE
Simvastatin BIS(T-BUTYLDIMETHYLSILOXY)ETHANE Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate 5-(TERT-BUTYLDIMETHYLSILYLOXY)-1-PENTANOL (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
chevron_left

1of3

chevron_right

tert-Butyldimethylsilyl chloride Suppliers

Global( 637)Suppliers
Supplier Tel Email Country ProdList Advantage
Haimen Best Fine Chemical Co., Ltd 		+8613862889628 best@bestfine.com China 1 58
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail：sales03@shyrchem.com sales03@shyrchem.com CHINA 739 60
Nanjing Sinoda Biological Technology Co., Ltd
+8613401983379 sales@njmcn.cn CHINA 74 58
BAODING STORD IMPORT AND EXPORT CO.,LTD
+8618603329229 luis.manager113@foxmail.com China 293 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 19994 60
Henan DaKen Chemical CO.,LTD. 		+86-371-66670886 info@dakenchem.com China 16666 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1815 55
Henan Tianfu Chemical Co.,Ltd. 		0371-55170693 info@tianfuchem.com China 22021 55
Shanghai Time Chemicals CO., Ltd. 		021-57951555 +8618017249410 jack.li@time-chemicals.com China 1809 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 fandachem@gmail.com China 9382 55
Supplier Advantage
Haimen Best Fine Chemical Co., Ltd 		58
Shanghai Yingrui Biopharma Co., Ltd.
60
Nanjing Sinoda Biological Technology Co., Ltd
58
BAODING STORD IMPORT AND EXPORT CO.,LTD
58
Capot Chemical Co.,Ltd. 		60
Henan DaKen Chemical CO.,LTD. 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

Related articles

View Lastest Price from tert-Butyldimethylsilyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-25 tert-Butyldimethylsilyl chloride
18162-48-6
 US $6.90 / KG 1KG 99% 100tons Hong Kong Tiansheng New Material Trading Co., Ltd
2021-11-11 tert-Butyldimethylsilyl chloride
18162-48-6
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-09-23 tert-Butyldimethylsilyl chloride
18162-48-6
 US $1.00 / Kg/Drum 1KG 99% Min 20mt per month Wuhan KEMI-WORKS Chemical Co., Ltd.

tert-Butyldimethylsilyl chloride Spectrum

tert-Butyldimethylsilyl chloride(18162-48-6)IR1

18162-48-6(tert-Butyldimethylsilyl chloride)Related Search:

TERT-BUTYLDIMETHYL(2-PROPYNYLOXY)SILANE Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester TERT-BUTYL VINYL ETHER tert-Butylchlorodiphenylsilane Triethylsilane
TERT-BUTYLDIMETHYLSILYL (S)-(-)-GLYCIDY& 2-Chloro-2-methylpropane Butylated hydroxyanisole BREDERECK'S REAGENT TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Dichloromethylsilane 3-CYANOPROPYLMETHYLDICHLOROSILANE 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile
DIMETHYLSILANE T-BUTYLDIMETHYLSILANE Recombinant Human Telomerase
chevron_left

1of4

chevron_right
SILANE TBM2 T-BUTYLDIMENHYLSILYL CHLORIDE t-butyl dimethyl chlorsilane TBUME2SI-CL TERT-BUTYLDIMETHYLSILYL CHLORIDE T-butyldimethylsilyl chloride*crystalline tert-Butyl Dimethylchlorosilane (TBDMSCl) chloro-dimethyl-tert-butyl-silane Tert-butyldimethylsilyl chloride, TBSCI TERT-BUTYLDIMETHYLSILYL CHLORIDE, 50 WT. % SOLUTION IN TOLUENE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, ~50% IN TOLUENE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, 50% IN METHYL. CHL. tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] tert-Butyldimethylchlorosilane, 97+% tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl t-BUTYLDIMETHYLCHLOROSILANE, 2.85M in toluene, 49-50% solution t-BUTYLDIMETHYLCHLOROSILANE, 3M in tetrahydrofuran tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, Silane TBM2-Tol Sol., TBDMSCl solution tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, Silane TBM2, TBDMSCl tert-Butylchlorodimethylsilane1.0M solution in dichloromethaneAcroSeal§3 t-Butyldimethylchlorosilane,min.97% TERT-BUTYLDIMETHYLCHLOROSILANE, 1.0 M IN METHYLENE CHLORIDE 2.85M IN TOLUENE (CA. 49.5%) TERT-BUTYLDIMETHYLCHLOROSILANE, 3M IN THF tert-Butylchlorodimethylsilane, 1.0M solution in dichloromethane tert-ButyldimethylchlorosilaneTBSCl tert-BUTYLDIMETHYLCHLOROSILANE 98% TERT-BUTYLDIMETHYLSILYL CHLORIDE (TBDMSCL) Tert-Butyldimethylchlorosilane50%W/WInToluene Tertbutyldimethylchlorosilane,ProtectiveReagent, Tbdmscl(Tert-ButyldimethylsilylChloride) Tert-ButyldimethylchlorosilaneTbms TBSCl (Tert-butyldimethylsilyl chloride) BDCS SILYLATION REAGENT CB2790 chloro(1,1-dimethylethyl)dimethyl-silan chloro(1,1-dimethylethyl)dimethyl-Silane chloro-tert-butyldimethyl-silan Chloro-tert-butyldimethylsilane Dimethyl-tert-butylchlorosilane Silane, t-butylchlorodimethyl- tbdmschloride TERT-BUTYLDIMETHYLSILYL CHLORIDE, 1.0M S OLUTION IN DICHLOROMETHANE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, ~1 M IN THF TERT-BUTYLDIMETHYLSILYL CHLORIDE, 1.0M S OLUTION IN TETRAHYDROFURAN TERT-BUTYLDIMETHYLCHLOROSILANE 98+% TERT-BUTYLL DIMETHYLCHOROSILANE t-butylchlorodimethyl-silane T-BUTYLDIMETHYLCHLOROSILANE, 2.85M IN TOLUENE T-BUTYLDIMETHYLCHLOROSILANE, 3M IN THF T-BUTYLDIMETHYLCHLOROSILANE, 1.0M IN METHYLENE CHLORIDE tert-Butyldimethylchlorosilane ,99% tert-Butylchlorodimethylsilane solution,tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution tert-Butyldimethylsilychloride tert-Butyldimethylsilyl chloride,tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl tert-Butyldimethylsilyl chloride solution,tert-Butylchlorodimethylsilane solution, tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution