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tert-Butyldimethylsilyl chloride

Chemical Name:
tert-Butyldimethylsilyl chloride
Molecular Formula:
Molecular Weight:
MOL File:
MSDS File:

tert-Butyldimethylsilyl chloride Properties

Melting point 86-89 °C (lit.)
Boiling point 125 °C (lit.)
Density 0.87 g/mL at 20 °C(lit.)
refractive index n20/D 1.46
Flash point 73 °F
storage temp. Store below +30°C.
solubility very sol nearly all common organic solvents such as THF, methylene chloride, and DMF.
form Liquid
color Clear colorless
Specific Gravity 1.225
Water Solubility Soluble in chloroform and ethyl acetate. Insoluble in water.
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
BRN 505999
CAS DataBase Reference 18162-48-6(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms BDCS
NIST Chemistry Reference Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA Substance Registry System Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)


Risk and Safety Statements

Signal word  Danger
Hazard statements  H225-H304-H314-H336-H361d-H373-H302-H335-H351-H226-H228-H318-H361
Precautionary statements  P309-P240-P241-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P210-P261-P280-P301+P310-P305+P351+P338-P310-P260-P370+P378-P403+P235
Hazard Codes  C,F,T,Xn
Risk Statements  22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements  26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR  UN 2925 4.1/PG 2
WGK Germany  2
RTECS  VV2000000
Hazard Note  Flammable/Corrosive/Moisture Sensitive
HazardClass  4.1
PackingGroup  III
HS Code  29310095
NFPA 704
3 0

tert-Butyldimethylsilyl chloride price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18642 tert-Butyldimethylchlorosilane for synthesis 18162-48-6 25g $153 2022-05-15 Buy
Sigma-Aldrich 8.18642 tert-Butyldimethylchlorosilane for synthesis 18162-48-6 100g $292 2022-05-15 Buy
Sigma-Aldrich 06735 tert-Butyldimethylsilyl chloride for GC derivatization, ≥99.0% (GC) 18162-48-6 10g $109 2022-05-15 Buy
TCI Chemical B0995 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) 18162-48-6 5g $24 2022-04-27 Buy
TCI Chemical B0995 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) 18162-48-6 25g $72 2022-04-27 Buy
Product number Packaging Price Buy
8.18642 25g $153 Buy
8.18642 100g $292 Buy
06735 10g $109 Buy
B0995 5g $24 Buy
B0995 25g $72 Buy

tert-Butyldimethylsilyl chloride Chemical Properties,Uses,Production

Chemical Properties

tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.


tert-Butyldimethylsilyl Chloride is a chemical used to protect alcohols during organic synthesis.


tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.


t-Butyldimethylchlorosilane is useful as an anion trapping reagent. For example, TBDMSCl was found to be an efficient trap of the lithio α-phenylthiocyclopropane anion.When dichlorothiophene was treated with 2 equiv of n-butyllithium followed by 2 equiv of TBDMSCl the di-TBDMS-thiophene was isolated. The lithium anions of primary (eq 1) and secondary (eq 2) nitriles were trapped with TBDMSCl to give C,N-disilyl- and Nsilylketenimines in excellent yields.
Silyl stannanes have been prepared by trapping tin anions with TBDMSCl or other silyl chlorides. Alkynes treated with silyl stannanes and catalytic tetrakis(triphenylphosphine)palladium(0) give cis-silyl stannylalkenes in good yields.


tert-butyldimethylsilyl chloride (TBSCI, mp 86–89 °C) is expensive though it is readily prepared in high yield by the reaction of tert-butyllithium with dichlorodimethylsilane.


ChEBI: Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.


tert-Butyldimethylsilyl chloride reacts with alcohols in the presence of base to give tert-butyldimethylsilyl ethers:(Me3C)Me2SiCl + ROH → (Me3C)Me2SiOR + HCl
These silyl ethers hydrolyze much more slowly than the trimethylsilyl ethers.


Moderately toxic.

Purification Methods

Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]

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View Lastest Price from tert-Butyldimethylsilyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-25 tert-Butyldimethylsilyl chloride
US $6.90 / KG 1KG 99% 100tons Hong Kong Tiansheng New Material Trading Co., Ltd
2021-11-11 tert-Butyldimethylsilyl chloride
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-09-23 tert-Butyldimethylsilyl chloride
US $1.00 / Kg/Drum 1KG 99% Min 20mt per month Wuhan KEMI-WORKS Chemical Co., Ltd.

tert-Butyldimethylsilyl chloride Spectrum

SILANE TBM2 T-BUTYLDIMENHYLSILYL CHLORIDE t-butyl dimethyl chlorsilane TBUME2SI-CL TERT-BUTYLDIMETHYLSILYL CHLORIDE T-butyldimethylsilyl chloride*crystalline tert-Butyl Dimethylchlorosilane (TBDMSCl) chloro-dimethyl-tert-butyl-silane Tert-butyldimethylsilyl chloride, TBSCI TERT-BUTYLDIMETHYLSILYL CHLORIDE, 50 WT. % SOLUTION IN TOLUENE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, ~50% IN TOLUENE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, 50% IN METHYL. CHL. tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] tert-Butyldimethylchlorosilane, 97+% tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl t-BUTYLDIMETHYLCHLOROSILANE, 2.85M in toluene, 49-50% solution t-BUTYLDIMETHYLCHLOROSILANE, 3M in tetrahydrofuran tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, Silane TBM2-Tol Sol., TBDMSCl solution tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, Silane TBM2, TBDMSCl tert-Butylchlorodimethylsilane1.0M solution in dichloromethaneAcroSeal§3 t-Butyldimethylchlorosilane,min.97% TERT-BUTYLDIMETHYLCHLOROSILANE, 1.0 M IN METHYLENE CHLORIDE 2.85M IN TOLUENE (CA. 49.5%) TERT-BUTYLDIMETHYLCHLOROSILANE, 3M IN THF tert-Butylchlorodimethylsilane, 1.0M solution in dichloromethane tert-ButyldimethylchlorosilaneTBSCl tert-BUTYLDIMETHYLCHLOROSILANE 98% TERT-BUTYLDIMETHYLSILYL CHLORIDE (TBDMSCL) Tert-Butyldimethylchlorosilane50%W/WInToluene Tertbutyldimethylchlorosilane,ProtectiveReagent, Tbdmscl(Tert-ButyldimethylsilylChloride) Tert-ButyldimethylchlorosilaneTbms TBSCl (Tert-butyldimethylsilyl chloride) BDCS SILYLATION REAGENT CB2790 chloro(1,1-dimethylethyl)dimethyl-silan chloro(1,1-dimethylethyl)dimethyl-Silane chloro-tert-butyldimethyl-silan Chloro-tert-butyldimethylsilane Dimethyl-tert-butylchlorosilane Silane, t-butylchlorodimethyl- tbdmschloride TERT-BUTYLDIMETHYLSILYL CHLORIDE, 1.0M S OLUTION IN DICHLOROMETHANE TERT-BUTYLDIMETHYLCHLOROSILANE SOLUTION, ~1 M IN THF TERT-BUTYLDIMETHYLSILYL CHLORIDE, 1.0M S OLUTION IN TETRAHYDROFURAN TERT-BUTYLDIMETHYLCHLOROSILANE 98+% TERT-BUTYLL DIMETHYLCHOROSILANE t-butylchlorodimethyl-silane T-BUTYLDIMETHYLCHLOROSILANE, 2.85M IN TOLUENE T-BUTYLDIMETHYLCHLOROSILANE, 3M IN THF T-BUTYLDIMETHYLCHLOROSILANE, 1.0M IN METHYLENE CHLORIDE tert-Butyldimethylchlorosilane ,99% tert-Butylchlorodimethylsilane solution,tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution tert-Butyldimethylsilychloride tert-Butyldimethylsilyl chloride,tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl tert-Butyldimethylsilyl chloride solution,tert-Butylchlorodimethylsilane solution, tert-Butyldimethylchlorosilane, tert-Butyldimethylsilyl chloride, TBDMSCl solution