tert-Butyldimethylsilyl chloride
- CAS No.
- 18162-48-6
- Chemical Name:
- tert-Butyldimethylsilyl chloride
- Synonyms
- TBSCL;TBDMSCL;TERT-BUTYLCHLORODIMETHYLSILANE;T-BUTYLDIMETHYLSILYL CHLORIDE;TBDMSCI;TERT-BUTYLDIMETHYLCHLOROSILANE;tert-Butyldimethylsilyl;SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL-;TBDMCl;T-BUTYLDIMETHYLCHLOROSILANE
- CBNumber:
- CB3763003
- Molecular Formula:
- C6H15ClSi
- Molecular Weight:
- 150.72
- MOL File:
- 18162-48-6.mol
- MSDS File:
- SDS
Melting point | 86-89 °C (lit.) |
---|---|
Boiling point | 125 °C (lit.) |
Density | 0.87 g/mL at 20 °C(lit.) |
refractive index |
n |
Flash point | 73 °F |
storage temp. | Store below +30°C. |
solubility | very sol nearly all common organic solvents such as THF, methylene chloride, and DMF. |
form | Liquid |
color | Clear colorless |
Specific Gravity | 1.225 |
Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
Sensitive | Moisture Sensitive |
Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
BRN | 505999 |
InChIKey | BCNZYOJHNLTNEZ-UHFFFAOYSA-N |
CAS DataBase Reference | 18162-48-6(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 550OPF5Z9F |
NCI Dictionary of Cancer Terms | BDCS |
NIST Chemistry Reference | Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6) |
EPA Substance Registry System | Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() ![]() GHS07,GHS08,GHS02,GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H304-H314-H336-H361d-H373-H302-H335-H351-H226-H228-H318-H361 | |||||||||
Precautionary statements | P309-P240-P241-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P210-P261-P280-P301+P310-P305+P351+P338-P310-P260-P370+P378-P403+P235 | |||||||||
Hazard Codes | C,F,T,Xn | |||||||||
Risk Statements | 22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38 | |||||||||
Safety Statements | 26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37 | |||||||||
RIDADR | UN 2925 4.1/PG 2 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | VV2000000 | |||||||||
F | 10-21 | |||||||||
Hazard Note | Flammable/Corrosive/Moisture Sensitive | |||||||||
TSCA | Yes | |||||||||
HazardClass | 4.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29310095 | |||||||||
NFPA 704 |
|
tert-Butyldimethylsilyl chloride price More Price(59)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 8.18642 | tert-Butyldimethylchlorosilane for synthesis | 18162-48-6 | 25g | $153 | 2022-05-15 | Buy |
Sigma-Aldrich | 8.18642 | tert-Butyldimethylchlorosilane for synthesis | 18162-48-6 | 100g | $292 | 2022-05-15 | Buy |
Sigma-Aldrich | 06735 | tert-Butyldimethylsilyl chloride for GC derivatization, ≥99.0% (GC) | 18162-48-6 | 10g | $109 | 2022-05-15 | Buy |
TCI Chemical | B0995 | tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) | 18162-48-6 | 5g | $24 | 2022-04-27 | Buy |
TCI Chemical | B0995 | tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC) | 18162-48-6 | 25g | $72 | 2022-04-27 | Buy |
tert-Butyldimethylsilyl chloride Chemical Properties,Uses,Production
Chemical Properties
tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.
Uses
tert-Butyldimethylsilyl Chloride is a chemical used to protect alcohols during organic synthesis.
Uses
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.
Uses
t-Butyldimethylchlorosilane is useful as an anion trapping reagent.
For example, TBDMSCl was found to be an efficient trap of
the lithio α-phenylthiocyclopropane anion.When dichlorothiophene
was treated with 2 equiv of n-butyllithium followed by
2 equiv of TBDMSCl the di-TBDMS-thiophene was isolated.
The lithium anions of primary (eq 1) and secondary (eq 2)
nitriles were trapped with TBDMSCl to give C,N-disilyl- and Nsilylketenimines
in excellent yields.
Silyl stannanes have been prepared by trapping tin anions with
TBDMSCl or other silyl chlorides. Alkynes treated with silyl stannanes
and catalytic tetrakis(triphenylphosphine)palladium(0) give
cis-silyl stannylalkenes in good yields.
Preparation
tert-butyldimethylsilyl chloride (TBSCI, mp 86–89 °C) is expensive though it is readily prepared in high yield by the reaction of tert-butyllithium with dichlorodimethylsilane.
Definition
ChEBI: Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.
Reactions
tert-Butyldimethylsilyl chloride reacts with alcohols in the presence of base to give tert-butyldimethylsilyl ethers:(Me3C)Me2SiCl + ROH → (Me3C)Me2SiOR + HCl
These silyl ethers hydrolyze much more slowly than the trimethylsilyl ethers.
Hazard
Moderately toxic.
Purification Methods
Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]
tert-Butyldimethylsilyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Haimen Best Fine Chemical Co., Ltd | +8613862889628 | best@bestfine.com | China | 1 | 58 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 E-mail:sales03@shyrchem.com | sales03@shyrchem.com | CHINA | 739 | 60 |
Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
BAODING STORD IMPORT AND EXPORT CO.,LTD | +8618603329229 | luis.manager113@foxmail.com | China | 293 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 19994 | 60 |
Henan DaKen Chemical CO.,LTD. | +86-371-66670886 | info@dakenchem.com | China | 16666 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1815 | 55 |
Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 | info@tianfuchem.com | China | 22021 | 55 |
Shanghai Time Chemicals CO., Ltd. | 021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1809 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 | fandachem@gmail.com | China | 9382 | 55 |
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View Lastest Price from tert-Butyldimethylsilyl chloride manufacturers
Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2022-02-25 | tert-Butyldimethylsilyl chloride
18162-48-6
|
US $6.90 / KG | 1KG | 99% | 100tons | Hong Kong Tiansheng New Material Trading Co., Ltd | |
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2021-11-11 | tert-Butyldimethylsilyl chloride
18162-48-6
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
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2021-09-23 | tert-Butyldimethylsilyl chloride
18162-48-6
|
US $1.00 / Kg/Drum | 1KG | 99% Min | 20mt per month | Wuhan KEMI-WORKS Chemical Co., Ltd. |
-
- tert-Butyldimethylsilyl chloride
18162-48-6
- US $6.90 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- tert-Butyldimethylsilyl chloride
18162-48-6
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- tert-Butyldimethylsilyl chloride
18162-48-6
- US $1.00 / Kg/Drum
- 99% Min
- Wuhan KEMI-WORKS Chemical Co., Ltd.
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