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1-BROMO-2-METHOXYNAPHTHALENE

1-BROMO-2-METHOXYNAPHTHALENE structure

CAS No.: 3401-47-6

Chemical Name:: 1-BROMO-2-METHOXYNAPHTHALENE

Synonyms: 1-Bromo-2-methoxynapthalene;2-Methoxy-1-naphtyl bromide;1-BROMO-2-METHOXYNAPHTHALENE;Naphthalene, 1-broMo-2-Methoxy-;1-Bromo-2-Naphthalene Methyl Ether;1-Bromo-2-methoxynaphthalene, >=97%

CBNumber:: CB0312286

Molecular Formula:: C11H9BrO

Molecular Weight:: 237.09

MDL Number:: MFCD00055374

MOL File:: 3401-47-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:49

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1-BROMO-2-METHOXYNAPHTHALENE Properties

Melting point	80-83 °C
Boiling point	190-192 °C(Press: 22 Torr)
Density	1.447±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
color	White to Light yellow
Water Solubility	Slightly soluble in water.
BRN	2045600
InChI	InChI=1S/C11H9BrO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,1H3
InChIKey	XNIGURFWNPLWJM-UHFFFAOYSA-N
SMILES	C1(Br)=C2C(C=CC=C2)=CC=C1OC
CAS DataBase Reference	3401-47-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29093090

NFPA 704

	1
0		0

1-BROMO-2-METHOXYNAPHTHALENE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B6103	1-Bromo-2-methoxynaphthalene	3401-47-6	5G	$54	2025-07-31	Buy
TCI Chemical	B6103	1-Bromo-2-methoxynaphthalene	3401-47-6	25G	$188	2025-07-31	Buy
TRC	B685775	1-Bromo-2-methoxy-naphthalene	3401-47-6	100g	$495	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0009985	1-BROMO-2-METHOXYNAPHTHALENE 95.00%	3401-47-6	1G	$629.53	2021-12-16	Buy
Biosynth Carbosynth	FB140571	1-Bromo-2-methoxynaphthalene	3401-47-6	100g	$636	2021-12-16	Buy

Product number	Packaging	Price	Buy
B6103	5G	$54	Buy
B6103	25G	$188	Buy
B685775	100g	$495	Buy
HCH0009985	1G	$629.53	Buy
FB140571	100g	$636	Buy

1-BROMO-2-METHOXYNAPHTHALENE Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

1-Bromo-2-methoxy-naphthalene is a useful synthetic intermediate. It is used as a reagent to synthesize a catalyst for highly enantioselective aziridination of styrene derivatives. It can also be used to prepare biaryls or biheterocycles by palladium-catalyzed Ullmann coupling.

Synthesis

573-97-7

74-88-4

3401-47-6

In a 500 mL round-bottomed three-necked flask, 1-bromo-2-naphthol (30.0 g, 134.5 mmol), potassium hydroxide (KOH, 11.3 g, 201.7 mmol) and 300 mL of dimethylsulfoxide (DMSO) were added, and stirred under nitrogen protection for 10 min. Subsequently, the reaction system was cooled in an ice-water bath and iodomethane (28.6 g, 201.7 mmol) was added dropwise slowly. After the dropwise addition, stirring was continued at room temperature under nitrogen atmosphere for 12 h. The reaction was then warmed up to 50 °C for 1 h. The reaction was then completed by cooling to 50 °C for 10 min. After completion of the reaction, it was cooled to room temperature. The reaction mixture was poured into 500 mL of water and extracted with ether. The organic phase was washed three times with distilled water and dried over anhydrous magnesium sulfate (MgSO4). After the solvent was evaporated under reduced pressure, it was purified by silica gel column chromatography (eluent: n-hexane) to afford 1-bromo-2-methoxynaphthalene 22.0 g (yield 69.0%) as a white solid.

References

[1] Patent: KR2016/17530, 2016, A. Location in patent: Paragraph 0238; 0241; 0245; 0246
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 24, p. 4800 - 4818
[3] Journal of Organic Chemistry, 2000, vol. 65, # 5, p. 1511 - 1515
[4] Patent: JP5656843, 2015, B2. Location in patent: Paragraph 0092; 0093
[5] Journal of the Chemical Society, 1900, vol. 77, p. 37

1-BROMO-2-METHOXYNAPHTHALENE Preparation Products And Raw materials

Raw materials

2-Methoxynaphthalene 1-Bromo-2-naphthol Iodomethane Potassium hydroxide Dimethyl sulfoxide

Preparation Products

2-METHOXY-1-NAPHTHOIC ACID 3-Methoxynaphthalene-2-boronic acid (2-METHOXY-1-NAPHTHYL)BORONIC ACID 1,6-DIBROMO-2-METHOXYNAPHTHALENE

1-BROMO-2-METHOXYNAPHTHALENE Suppliers

Global( 210)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Mujin Biotechnology Co.,Ltd	+86-13288715578	sales@hbmojin.com	China	12648	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20202	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	12828	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	925	55
Zhengzhou HQ Material CO.,LTD.	+86-371-55919009 +8615225108189	sale1@hqmat.com	China	1001	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29804	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	3974	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Time Chemicals CO., Ltd.	55
Speranza Chemical Co., Ltd.	55
Zhengzhou HQ Material CO.,LTD.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 1-BROMO-2-METHOXYNAPHTHALENE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-07	1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6	US $0.00 / kg	1kg	99%	1000tons	Hebei Mujin Biotechnology Co.,Ltd
2025-06-24	1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-19	1-BROMO-2-METHOXYNAPHTHALENE 3401-47-6	US $0.00-0.00 / KG	1KG	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.

1-BROMO-2-METHOXYNAPHTHALENE
3401-47-6
US $0.00 / kg
99%
Hebei Mujin Biotechnology Co.,Ltd

1-BROMO-2-METHOXYNAPHTHALENE
3401-47-6
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-BROMO-2-METHOXYNAPHTHALENE
3401-47-6
US $0.00-0.00 / KG
98%
Shenzhen Nexcon Pharmatechs Ltd.

1-BROMO-2-METHOXYNAPHTHALENE Spectrum

1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)MS 1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)¹HNMR 1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)IR1 1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)IR2

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