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Conivaptan impurity

Conivaptan impurity structure

CAS No.: 1129433-63-1

Chemical Name:: Conivaptan impurity

Synonyms: Conivaptan-d4;N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide

CBNumber:: CB03144862

Molecular Formula:: C32H26N4O2

Molecular Weight:: 498.59

MDL Number:

MOL File:: 1129433-63-1.mol

Last updated:2023-05-21 10:59:17

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Conivaptan impurity Properties

storage temp.	Store at -20°C
solubility	DMSO: soluble
form	A solid

Conivaptan impurity price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	26455	Conivaptan-d4	1129433-63-1	500μg	$194	2024-03-01	Buy
Cayman Chemical	26455	Conivaptan-d4	1129433-63-1	1mg	$369	2024-03-01	Buy
AK Scientific	3226DC	2-Phenyl-N-[2,3,5,6-tetradeuterio-4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]benzamide	1129433-63-1	1mg	$753	2021-12-16	Buy

Product number	Packaging	Price	Buy
26455	500μg	$194	Buy
26455	1mg	$369	Buy
3226DC	1mg	$753	Buy

Conivaptan impurity Chemical Properties,Uses,Production

Biological Activity

Conivaptan-d4 is intended for use as an internal standard for the quantification of conivaptan by GC- or LC-MS. Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively).1 It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.2

References

1.Tahara, A., Tomura, Y., Wada, K.-I., et al.Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivoJ. Pharmacol. Exp. Ther.282(1)301-308(1997) 2.Zeynalov, E., Jones, S.M., Seo, J.W., et al.Arginine-vasopressin receptor blocker conivaptan reduces brain edema and blood-brain barrier disruption after experimental stroke in micePLoS One10(8)e0136121(2015)

Conivaptan impurity Preparation Products And Raw materials

Raw materials

Preparation Products

Conivaptan impurity Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD	0755-0755-0755-83725350 13380397412	3001280422@qq.com	China	9924	58
Shanghai isotope chemical co.,ltd	021-021-51600108 13062666369	sales@chinaisotope.com	China	4272	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Hubei Moco Chemical Co., Ltd.	17386083646	2853567991@qq.com	China	10469	58

Supplier	Advantage
Pharmacodia (Beijing) Co.,Ltd	55
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD	58
Shanghai isotope chemical co.,ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Hubei Moco Chemical Co., Ltd.	58

1129433-63-1(Conivaptan impurity)Related Search:

2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Conivaptan hydrochloride 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

N-(4-(2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxaMide

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Conivaptan-d4 N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide 1129433-63-1