ChemicalBook >> CAS DataBase List >>CA-5f
CA-5f
- CAS No.
- 1370032-19-1
- Chemical Name:
- CA-5f
- Synonyms
- CA-5f;CA-5F;CA 5F;CA5F;1370032-19-1;-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f;(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one;(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one;4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- CBNumber:
- CB04808619
- Molecular Formula:
- C24H24N2O3
- Molecular Weight:
- 388.46
- MDL Number:
- MOL File:
- 1370032-19-1.mol
Last updated:2023-05-21 10:59:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
CA-5f price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb573239 | CA-5f >98% | 1370032-19-1 | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573182 | CA-5f >98% | 1370032-19-1 | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573239 | CA-5f >98% | 1370032-19-1 | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573182 | CA-5f >98% | 1370032-19-1 | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573239 | CA-5f >98% | 1370032-19-1 | 1g | $2839 | 2021-12-16 | Buy |
CA-5f Chemical Properties,Uses,Production
Biological Activity
CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity.
in vivo
CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
| Animal Model: | < td class="col2"> Nude mice bearing A549 lung cancer cells|
| Dosage: | 40 mg /kg |
| Administration: | Injected via caudal vein, every 2 days for up to 30 days < /td> |
| Result: | Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice . |
target
Macroautophagy/autophagy
CA-5f Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| Giant chemicals | 028-85434334 18108076537 | market@gianthx.com | China | 4512 | 56 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9838 | 58 |
CA-5f
CA-5F;CA 5F;CA5F;1370032-19-1
4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one
CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f
(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
1370032-19-1
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