BIBU 1361 DIHYDROCHLORIDE
- CAS No.
- 793726-84-8
- Chemical Name:
- BIBU 1361 DIHYDROCHLORIDE
- Synonyms
- BIBU 1361;BIBU1361 (BIBU 1361 );BIBU 1361 DIHYDROCHLORIDE;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine;Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride;N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE
- CBNumber:
- CB0840882
- Molecular Formula:
- C22H27ClFN7
- Molecular Weight:
- 443.95
- MDL Number:
- MFCD08703120
- MOL File:
- 793726-84-8.mol
BIBU 1361 DIHYDROCHLORIDE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2417 | BIBU1361dihydrochloride ≥97%(HPLC) | 793726-84-8 | 10 | $169 | 2021-12-16 | Buy |
| Usbiological | 254751 | BIBU 1361 dihydrochloride | 793726-84-8 | 1mg | $360 | 2021-12-16 | Buy |
| ApexBio Technology | B7048 | BIBU1361dihydrochloride | 793726-84-8 | 10mg | $380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000049 | BIBU 1361 DIHYDROCHLORIDE 95.00% | 793726-84-8 | 1MG | $636.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000049 | BIBU 1361 DIHYDROCHLORIDE 95.00% | 793726-84-8 | 10MG | $757.97 | 2021-12-16 | Buy |
BIBU 1361 DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
References
[1]. antczak c, mahida jp, bhinder b, et al. a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function implications in drug discovery. journal of biomolecular screening, 2012, 17(7): 885-899.
[2]. ghildiyal r, dixit d, sen e. egfr inhibitor bibu induces apoptosis and defective autophagy in glioma cells. molecular carcinogenesis, 2013, 52(12): 970-982.
BIBU 1361 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BIBU 1361 DIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |