CM 764
- CAS No.
- 1350296-29-5
- Chemical Name:
- CM 764
- Synonyms
- CM 764;2(3H)-Benzoxazolone, 6-acetyl-3-[4-[4-(2-amino-4-fluorophenyl)-1-piperazinyl]butyl]-
- CBNumber:
- CB09617940
- Molecular Formula:
- C23H27FN4O3
- Molecular Weight:
- 426.48
- MDL Number:
- MOL File:
- 1350296-29-5.mol
CM 764 Chemical Properties,Uses,Production
Description
CM764 is a potent and selective antagonist of sigma-2 receptors, a novel derivative of SN79.
Uses
CM764 is an activator for sigma receptor with Ki of 86.6 and 3.5 nM for sigma-1 receptor and sigma-2 receptor. CM764 increases cytoplasmic calcium, NAD+/NADH, and ATP levels, and decreases the concentration of ROS[1].
IC 50
Sigma 2 Receptor: 3.5 nM (Ki); Sigma 1 Receptor: 86.6 nM (Ki)
References
[1] Nicholson H, et al., Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. DOI:10.1124/jpet.115.228387
CM 764 Preparation Products And Raw materials
Raw materials
Preparation Products
CM 764 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
