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DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

CAS No.
13515-99-6
Chemical Name:
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
Synonyms
utamate HydrochL;H-DL-Glu(Ome)-Ome;DL-Glu(OMe)-OMe.HCl;H-DL-GLU(OME)-OME HCL;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE;DimethylDL-GlutamateHydrochloride>imethyl2-aminopentanedioate,hydrochloride;dimethyl 2-aminopentanedioate hydrochloride;DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP
CBNumber:
CB1152575
Molecular Formula:
C7H14ClNO4
Molecular Weight:
211.64
MDL Number:
MFCD00266895
MOL File:
13515-99-6.mol
MSDS File:
SDS
Last updated:2024-03-25 07:34:14

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Properties

Melting point 154 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
CAS DataBase Reference 13515-99-6
FDA UNII 16247QSY33

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
HS Code  2922.42.5000
NFPA 704
0
2 0

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D3305 Dimethyl DL-Glutamate Hydrochloride >98.0%(N)(T) 13515-99-6 5g $42 2024-03-01 Buy
TCI Chemical D3305 Dimethyl DL-Glutamate Hydrochloride >98.0%(N)(T) 13515-99-6 25g $120 2024-03-01 Buy
Cayman Chemical 18602 Dimethyl DL-Glutamate (hydrochloride) ≥95% 13515-99-6 5g $68 2024-03-01 Buy
Cayman Chemical 18602 Dimethyl DL-Glutamate (hydrochloride) ≥95% 13515-99-6 10g $130 2024-03-01 Buy
Cayman Chemical 18602 Dimethyl DL-Glutamate (hydrochloride) ≥95% 13515-99-6 25g $302 2024-03-01 Buy
Product number Packaging Price Buy
D3305 5g $42 Buy
D3305 25g $120 Buy
18602 5g $68 Buy
18602 10g $130 Buy
18602 25g $302 Buy

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

Uses

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

in vitro

dimethyl dl-glutamate at 3.0-10.0 mm could enhance insulin release evoked by 6.0-8.3 mm d-glucose, 1.0-10.0 mm l-leucine, or 5.0-10.0 mm 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and d-glucose concentration. moreover, dimethyl dl-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of d-glucose. in islets exposed to l-leucine, the insulinotropic action of dimethyl dl-glutamate coincided with an early fall and later increase in 86rb outflow. in addition, the overall gain in o2 uptake represented the balance between dimethyl dl-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous d-glucose [1].

in vivo

dimethyl dl-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. results showed that dimethyl dl-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glp-1 injected intravenously at min 5 of the test [2].

References

[1] sener, a. ,conget, i.,rasschaert, j., et al. insulinotropic action of glutamic acid dimethyl ester. american journal of physiology 267(4 pt 1), e573-e584 (1994).
[2] cancelas, j. ,villaneuva-peacarrillo, m.l.,valverde, i., et al. potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of l-glutamic acid in a type 2 diabetes animal model. endocrine 16(2), 113-116 (2001).

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd
+86-028-64841719 +8618980456393 daisy@enlaibio.com China 1369 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
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Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
GL Biochem (Shanghai) Ltd.
+86-021-61263370 +86-18901917034 CHINA 3904 58
GL Biochem(Binhai) Ltd.
+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58

View Lastest Price from DIMETHYL DL-GLUTAMATE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DL-Glu(Ome)-Ome.Hcl pictures 2024-03-29 DL-Glu(Ome)-Ome.Hcl
13515-99-6
US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
	DIMETHYL DL-GLUTAMATE HYDROCHLORIDE pictures 2019-07-06 DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
13515-99-6
US $1.00 / KG 1KG 99% 20kg Career Henan Chemical Co
DL-GLUTAMIC ACID ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE DIMETHYL DL-GLUTAMATE HYDROCHLORIDE H-DL-GLU(OME)-OME HCL dimethyl 2-aminopentanedioate hydrochloride DL-Glutamic Acid Dimethyl Ester Hydrochloride H-DL-Glu(OMe)-OMe.HCl DL-Glu(OMe)-OMe.HCl Dimethyl DL-Glutamate Hydrochloride H-DL-Glu(Ome)-Ome 1,5-dimethyl 2-aminopentanedioate hydrochloride DimethylDL-GlutamateHydrochloride> utamate HydrochL imethyl2-aminopentanedioate,hydrochloride DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP 13515-99-6 Amino Acids (C-Protected) Amino Acid Methyl Esters Protected & Labeled Amino Acids Amino Acid Methyl Esters Amino Acids Amino Acids (C-Protected) Biochemistry