MEDICA 16
- CAS No.
- 87272-20-6
- Chemical Name:
- MEDICA 16
- Synonyms
- MEDICA 16;MEDICA16, 10 mM in DMSO;3,3,14,14-TETRAMETHYLHEXADECANEDIOIC ACID;3,3,14,14-TETRAMETHYLHEXADECANEDIONIC ACID;Hexadecanedioic acid, 3,3,14,14-tetramethyl-;ACLY,antidiabetogenic,ATP Citrate Lyase,antidiabetic,skeletal,Inhibitor,MEDICA16,ligands,Free Fatty Acid Receptor,MEDICA-16,insulin,FFAR,endogenous,muscle,inhibit
- CBNumber:
- CB1175406
- Molecular Formula:
- C20H38O4
- Molecular Weight:
- 342.51
- MDL Number:
- MFCD00797684
- MOL File:
- 87272-20-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MEDICA 16 powder, ≥97% (HPLC) | M5693 | 5mg | $155 |
| MEDICA 16 ≥98% | 90290 | 1mg | $36 |
| MEDICA 16 ≥98% | 90290 | 5mg | $128 |
| MEDICA 16 ≥98% | 90290 | 10mg | $176 |
| MEDICA 16 ≥98% | 90290 | 50mg | $753 |
| More product size | |||
| Melting point | 154-159 °C |
|---|---|
| Boiling point | 485.9±18.0 °C(Predicted) |
| Density | 0.984±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: 28 mg/mL |
| pka | 4.51±0.10(Predicted) |
| form | solid |
| color | white |
| InChI | 1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24) |
| InChIKey | HYSMCRNFENOHJH-UHFFFAOYSA-N |
| SMILES | CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O |
| FDA UNII | TC257FLPCK |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
MEDICA 16 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5693 | MEDICA 16 powder, ≥97% (HPLC) | 87272-20-6 | 5mg | $155 | 2026-04-30 | Buy |
| Cayman Chemical | 90290 | MEDICA 16 ≥98% | 87272-20-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 90290 | MEDICA 16 ≥98% | 87272-20-6 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 90290 | MEDICA 16 ≥98% | 87272-20-6 | 10mg | $176 | 2026-04-30 | Buy |
| Cayman Chemical | 90290 | MEDICA 16 ≥98% | 87272-20-6 | 50mg | $753 | 2026-04-30 | Buy |
MEDICA 16 Chemical Properties,Uses,Production
Description
MEDICA 16 is a β,β''-
Uses
MEDICA 16 is a malic enzyme and mitochondrial glycerol-3-phosphate dehydrogenase inducer.
Uses
MEDICA 16 is a β,β'-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.
Definition
ChEBI: MEDICA 16 is an alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties. It has a role as an antilipemic drug, an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor, an EC 2.3.3.8 (ATP citrate synthase) inhibitor, a G-protein-coupled receptor agonist and a hypoglycemic agent.
storage
-20°C
References
[1] TAKAFUMI HARA. Novel selective ligands for free fatty acid receptors GPR120 and GPR40.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2009, 380 3: 247-255. DOI: 10.1007/s00210-009-0425-9
[2] TIMOTHY N. C. WELLS Barbara A S. Redox control of catalysis in ATP-citrate lyase from rat liver[J]. The FEBS journal, 1992, 204 1: 249-255. DOI: 10.1111/j.1432-1033.1992.tb16631.x
[3] L. L. ATKINSON. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.[J]. Diabetes, 2002, 51 5 1: 1548-1555. DOI: 10.2337/diabetes.51.5.1548
[4] J C RUSSELL. Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16.[J]. Diabetes, 1998, 47 5: 770-778. DOI: 10.2337/diabetes.47.5.770
MEDICA 16 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4769 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2989 | 58 |
