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L-Glutathione

L-Glutathione Structure
L-Glutathione structure
CAS No.
27025-41-8
Chemical Name:
L-Glutathione
Synonyms
GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;Bi(glutath
CBNumber:
CB1200803
Molecular Formula:
C20H32N6O12S2
Molecular Weight:
612.63
MDL Number:
MFCD00063106
MOL File:
27025-41-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
Glutathione Impurity C Pharmaceutical Secondary Standard; Certified Reference Material PHR2461 100mg $310
L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. G2299 100g $1700
L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. G2299 1kg $11200
Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 3542 1g $106
Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 3542 5G $292
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L-Glutathione Properties

Melting point 178 °C (dec.)(lit.)
alpha -99 º (c=4, water)
Density 1.3688 (rough estimate)
refractive index -105 ° (C=2, H2O)
storage temp. 2-8°C
solubility H2O: soluble
form powder
pka 2.12, 3.59, 8.75, 9.65(at 25℃)
color White to off-white
biological source synthetic
optical activity -111.016 (H2O)
Water Solubility soluble
Merck 13,4488
BRN 1718700
Stability Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
InChIKey YPZRWBKMTBYPTK-USZNOCQGSA-N
SMILES N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
CAS DataBase Reference 27025-41-8(CAS DataBase Reference)
FDA UNII ULW86O013H
EPA Substance Registry System Oxiglutatione (27025-41-8)
UNSPSC Code 41116107
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-36/37/39-27-37/39
WGK Germany  2
RTECS  MC0556500
HS Code  29309090
Storage Class 11 - Combustible Solids
Toxicity mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.
NFPA 704
0
2 0

L-Glutathione price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2461 Glutathione Impurity C Pharmaceutical Secondary Standard; Certified Reference Material 27025-41-8 100mg $310 2026-04-30 Buy
Sigma-Aldrich G2299 L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. 27025-41-8 100g $1700 2026-04-30 Buy
Sigma-Aldrich G2299 L-Glutathione oxidized PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. 27025-41-8 1kg $11200 2026-04-30 Buy
Sigma-Aldrich 3542 Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 27025-41-8 1g $106 2026-04-30 Buy
Sigma-Aldrich 3542 Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys 27025-41-8 5G $292 2026-04-30 Buy
Product number Packaging Price Buy
PHR2461 100mg $310 Buy
G2299 100g $1700 Buy
G2299 1kg $11200 Buy
3542 1g $106 Buy
3542 5G $292 Buy

L-Glutathione Chemical Properties,Uses,Production

Description

L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].

Uses

L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, L-Glutathione formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.

Application

L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Definition

ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).

Biochem/physiol Actions

L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Side effects

There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.

Purification Methods

Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]

References

[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.

L-Glutathione synthesis

57564-91-7
27025-41-8
10102-43-9
Synthesis of L-Glutathione from S-NITROSOGLUTATHIONE

L-Glutathione Preparation Products And Raw materials

Raw materials

Preparation Products

GLUTATHIONESULFONIC ACID norophthalamic acid

L-Glutathione Suppliers

Global( 644)Suppliers
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Hantai Biomedical Group Co. LTD
+8618819265912 id002@cnhantide.com China 37 58
Aladdin Scientific
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Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8736 58
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XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 		+86-029-86333380 +86-18829239519 sales06@tgybio.com China 898 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
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Supplier Advantage
Hantai Biomedical Group Co. LTD
58
Aladdin Scientific
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shanghai UCHEM Inc. 		58
Wuhan Fortuna Chemical Co., Ltd 		58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
henan kanbei chemical co.,ltd 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Hebei Jingbo New Material Technology Co., Ltd 		58

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View Lastest Price from L-Glutathione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L(-)-Glutathione pictures 2026-05-02 L(-)-Glutathione
27025-41-8
 0.99 RongNa Biotechnology Co.,Ltd
L(-)-Glutathione pictures 2026-04-30 L(-)-Glutathione
27025-41-8
 US $52.00-182.00 / g 5g 0.98 100kg Shanghai UCHEM Inc.
L-Glutathione pictures 2026-04-30 L-Glutathione
27025-41-8
 US $50.00-43.00 / Box 1Box 99% 2000 Shandong Huizhihan Supply Chain Co., Ltd
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    27025-41-8
  • US $50.00-43.00 / Box
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L-Glutathione Spectrum

L(-)-Glutathione(27025-41-8)1HNMRL(-)-Glutathione(27025-41-8)IR1L(-)-Glutathione(27025-41-8)Raman

27025-41-8(L-Glutathione)Related Search:

Thiamine disulfide GLUTATHIONE PEROXIDASE Glutathione S-LACTOYL-GLUTATHIONE METHYLGLYOXAL-LYASE [ISOMERIZING] NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE II,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE VI
L-GLUTATHIONE OXIDIZED,L-GLUTATHIONE (OXIDIZED FORM),L-GLUTATHIONE OXIDISED,GSSG L-GLUTATHIONE OXIDIZED DISODIUM SALT,GSSG DISODIUM SALT,GSSG , OXIDIZED FORM DISODIUM SALT S-NITROSO-L-GLUTATHIONE RX: GLUTATHIONE R-TRANSFERASE S-(LACTOYL)GLUTATHIONE
N,S-BIS-FMOC-GLUTATHIONE L-Glutathione GGKPDLRPCHPPCHYIPRPKPR L-CYSTEINE-GLUTATHIONE DISULFIDE,L-CYSTEINE-GLUTATHIONE DISULPHIDE ([15N]GLY)-GLUTATHIONE (REDUCED)
S-(1-PENTYL-5-BIOTINYLAMIDO)GLUTATHIONE S-(N,N-DIETHYLCARBAMOYL)GLUTATHIONE S-LINKED GLUTATHIONE AGAROSE,GLUTATHIONE-UNIFLOW RESIN,GLUTATHIONE-SUPERFLOW RESIN

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GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE OXIDIZED (-)-GLUTATHIONE, OXIDIZED GLUTATHIONE, OXIDIZED FORM CYCLIC(GAMMA-GLU-CYS-GLY) CYCLIC(GAMMA-GLU-CYS-GLY)2 bi(glutathion-S-yl) GLUTATHIONE OXIDIZED FORM FREE ACID*LYOP HILIZED POW ** APPROVAL REQ **GLUTATHIONE OXIDIZED GLUTATHIONE OXIDIZED FORM FREE ACID*GRAD E II GLUTATHIONE OXIDIZED FORM FREE ACID*SIGM AULTRA L(-)-Glutathione, oxidized, hydrate, 95% Glycine, L-.gamma.-glutamyl-L-cysteinyl-, bimol. (2?2)-disulfide 2-amino-4-[[2-[2-[(4-amino-4-carboxy-butanoyl)amino]-2-(carboxymethylcarbamoyl)ethyl]disulfanyl-1-(carboxymethylcarbamoyl)ethyl]carbamoyl]butanoic acid Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di- (7CI) Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-, L- (8CI) Glutathione-S-S-glutathione Glycine, L-g-glutamyl-L-cysteinyl-, bimol. (22')-disulfide (9CI) Oxidized L-glutathione Sleep-promoting factor B NOV-002 White lyophilizate L-Glutathione oxidized Vetec(TM) reagent grade, >=98% Glutathione(Oxidized Form), free acid n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin oxigluthione S,S’-Ethylenebis(glutathione) L-.GLUTATHIONE (OXIDIZED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE] GLUTATHIONE OXIDISED extrapure glutathione, oxidised Glutathiol, GSSG L-Glutathione oxidized, Glutathiol, GSSG 3,3'-Dithiobis[N-(carboxymethyl)-N2-(γ-glutamyl)alaninamide] N,N'-Bis(carboxymethyl)-Nα,Nα'-bis(γ-glutamyl)-L-cystinamide Oxyglutatione l-gamma-glutamyl-l-cysteinyl glycine L(-)-Glutathione, oxidized, hydrate,98+% L(-)-Glutathione, oxidized, hydrate,95% L(-)-Glutathione, oxidized,98% L-Glutathione oxidized,GSSG, Glutathiol ()-Glutathione, oxidized,L-Glutathione oxidized, GSSG, Glutathiol Glutathione Oxydized L(-)-Glutathionehydrate L(-)-Glutathione L(-)-Glutathione, oxidized, 98% 500MG N,N'-[Dithiobis[1-[(carboxyMethyl)carbaMoyl]ethylene]]diglutaMine GLT1JP-IN (L-GLUTATHIONE RED Glutathione IMpurity C (Disulfide IMpurity) glutathionedisulphide glutathione-ssg glutathonedisulfide Glycine,L-.gamma.-glutamyl-L-cysteinyl-,2,2’-disulfide glycine,l-gamma-glutamyl-l-cysteinyl-,(2,2’)-disulfide l-oxidizedglutathione N-(N-.gamma.-Glutamyl-cysteinyl)glycine-2,2-disulfide Glutathiol L-GLUTATHIONE (OXIDIZED FORM)