WP631

WP631 structure

CAS No.

Chemical Name:: WP631

Synonyms: WP631;WP631 2HCL

CBNumber:: CB1218211

Molecular Formula:: C62H66Cl2N2O20

Molecular Weight:: 1230.09

MDL Number:: MFCD08061905

MOL File:: Mol file

Last updated:2023-04-23 13:52:06

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WP631 Properties

storage temp.	-20°C (des,)
solubility	Soluble in DMSO (up to 5 mg/ml)
form	solid
color	Red
Stability	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

WP631 Chemical Properties,Uses,Production

Description

WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4? Abrogates HIV-1 replication via inhibition of Tat transactivation.5

References

Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402 Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584 Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273 Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86 Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652

WP631 Preparation Products And Raw materials

Raw materials

Preparation Products

WP631 Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Focus Biomolecules	--	sales@focusbiomolecules.com	United States	1284	58
Fluorochem Ltd	--	vernam@fluorochem.co.uk	United Kingdom	6383	65
A.G. Scientific, Inc.	--	support@agscientific.com	United States	1066	71
EMD Biosciences, Inc.	--	technical@calbiochem.com	United States	6529	66
Fluorochem Ltd.	--	enquiries@fluorochem.co.uk	United Kingdom	6406	74
VWR International	--	solutions@vwr.com	United Kingdom	6554	82

Supplier	Advantage
Focus Biomolecules	58
Fluorochem Ltd	65
A.G. Scientific, Inc.	71
EMD Biosciences, Inc.	66
Fluorochem Ltd.	74
VWR International	82

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WP631 WP631 2HCL