| Company Name: |
Focus Biomolecules
|
| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:WP631
Purity:>98% HPLCNMR (Conforms) Package:$65.00/100μg;$270.00/500μg;
|
| Company Name: |
Fluorochem Ltd
|
| Tel: |
(01457) 868921 (4 lines) |
| Email: |
vernam@fluorochem.co.uk |
| Products Intro: |
|
| Company Name: |
VWR International
|
| Tel: |
800 932 5000 |
| Email: |
solutions@vwr.com |
| Products Intro: |
|
| Company Name: |
Fluorochem Ltd.
|
| Tel: |
+44 1457 868921 |
| Email: |
enquiries@fluorochem.co.uk |
| Products Intro: |
|
|
| Product Name: | WP631 | | Synonyms: | WP631;WP631 2HCL | | CAS: | | | MF: | C62H66Cl2N2O20 | | MW: | 1230.09 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | WP631 Chemical Properties |
| storage temp. | -20°C (des,) | | solubility | Soluble in DMSO (up to 5 mg/ml) | | form | solid | | color | Red | | Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | WP631 Usage And Synthesis |
| Description | WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4? Abrogates HIV-1 replication via inhibition of Tat transactivation.5 | | References | Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402
Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584
Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273
Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86
Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652 |
| | WP631 Preparation Products And Raw materials |
|