N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- CAS No.
- 444731-74-2
- Chemical Name:
- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- Synonyms
- BNKY007-PZ01;Pazopanib Impurity 20;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001:2015 REACH
- CBNumber:
- CB12526161
- Molecular Formula:
- C13H12ClN5
- Molecular Weight:
- 273.72
- MDL Number:
- MFCD17014818
- MOL File:
- 444731-74-2.mol
- MSDS File:
- SDS
Melting point | >216oC (dec.) |
---|---|
Boiling point | 550.0±35.0 °C(Predicted) |
Density | 1.41±0.1 g/cm3(Predicted) |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 2.56±0.30(Predicted) |
color | Pale Orange to Light Brown |
Stability | Hygroscopic |
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C380080 | N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine | 444731-74-2 | 1g | $175 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC32848 | N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine | 444731-74-2 | 250mg | $315 | 2021-12-16 | Buy |
Matrix Scientific | 095743 | N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 95+% | 444731-74-2 | 250mg | $439 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC32848 | N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine | 444731-74-2 | 500mg | $525 | 2021-12-16 | Buy |
AK Scientific | X3179 | N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine | 444731-74-2 | 5g | $728 | 2021-12-16 | Buy |
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemical Properties,Uses,Production
Uses
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Application
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.
Synthesis
2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | 790226113@qq.com | China | 52 | 58 |
Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 | jennysun@yzqyyykj.com | China | 71 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-06-22 | N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
|
US $0.00 / g | 10g | 98% | 10tons | Yangzhou Qinyuan Pharmatech Co.,ltd | ||
2022-05-24 | N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
|
US $1.10 / g | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | ||
2019-07-06 | 2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-
444731-74-2
|
US $1.00 / KG | 1KG | 99% | 20tons | Career Henan Chemical Co |
- N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
- US $0.00 / g
- 98%
- Yangzhou Qinyuan Pharmatech Co.,ltd
- N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
- US $1.10 / g
- 99.0% Min
- Dideu Industries Group Limited
- 2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-
444731-74-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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