N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
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N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 속성
- 녹는점
- >216oC (dec.)
- 끓는 점
- 550.0±35.0 °C(Predicted)
- 밀도
- 1.41±0.1 g/cm3(Predicted)
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.56±0.30(Predicted)
- 색상
- 옅은 오렌지색에서 밝은 갈색까지
- 안정성
- 흡습성
안전
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine C화학적 특성, 용도, 생산
용도
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.주요 응용
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.Synthesis
2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 준비 용품 및 원자재
원자재
2,3-DIMETHYL-2H-INDAZOL-6-AMINE
2,3-dimethyl-2H-indazol-6-amine hydrochloride
2,4-Dichloropyrimidine
준비 용품
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 공급 업체
글로벌( 135)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 |
790226113@qq.com | China | 52 | 58 |
Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 |
jennysun@yzqyyykj.com | China | 71 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 |
chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 관련 검색:
Pazopanib Related Compound 3
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid
Pazopanib Impurity 9
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
Pazopanib
Pazopanib-d6
2,3-dimethyl-2H-indazol-6-amine hydrochloride
Pazopanib Related Compound 2
1,3-Dimethyl-6-nitro-1H-indazole
2-Methyl-5-nitrobenzenesulfonamide
3-AMINO-4-METHYLBENZENESULFONAMIDE
5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide
2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
1,3-DiMethyl-6-aMino-1H-indazole
4(1H)-Pyrimidinone, 2-chloro- (9CI)
Pazopanib Impurity 10