N3-PEG3-tBu
- CAS No.
- 252881-73-5
- Chemical Name:
- N3-PEG3-tBu
- Synonyms
- N3-PEG3-tBu;Azido-PEG3-COOtBu;N3-PEG3-CH2CH2-Boc;N?-PEG?-CH?CH?COOtBu;N3-PEG3-CH2CH2COOtBu;Azido-PEG3-tBu Ester;Azido-PEG3-CH2CH2COOtBu;N3-?PEG3-?t-?butyl ester;N3-(CH2CH2O)3-CH2CH2COOt-Bu;tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
- CBNumber:
- CB12546985
- Molecular Formula:
- C13H25N3O5
- Molecular Weight:
- 303.3547
- MDL Number:
- MFCD22201543
- MOL File:
- 252881-73-5.mol
- MSDS File:
- SDS
N3-PEG3-tBu price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A925065 | Azido-PEG3-t-butylEster | 252881-73-5 | 1g | $315 | 2021-12-16 | Buy |
| BroadPharm | BP-20637 | Azido-PEG3-t-butylester 98% | 252881-73-5 | 500mg | $320 | 2021-12-16 | Buy |
| BroadPharm | BP-20637 | Azido-PEG3-t-butylester 98% | 252881-73-5 | 1g | $440 | 2021-12-16 | Buy |
| ChemPep | 280701 | N3-PEG3-tBu | 252881-73-5 | 1g | $449 | 2021-12-16 | Buy |
| AK Scientific | AMTGC716 | tert-butyl3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate | 252881-73-5 | 5g | $660 | 2021-12-16 | Buy |
N3-PEG3-tBu Chemical Properties,Uses,Production
Description
Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
Biological Activity
N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Alkyl/ether
| Cleavable
|
N3-PEG3-tBu Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
View Lastest Price from N3-PEG3-tBu manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-24 | azido-PEG3-t-Butyl ester
252881-73-5
|
US $0.00 / g | 1g | >98.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- azido-PEG3-t-Butyl ester
252881-73-5
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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