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ChemicalBook >> CAS DataBase List >>Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Structure
Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester structure
CAS No.
1246213-45-5
Chemical Name:
Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester
Synonyms
Ivacaftor Methylcarbonate;N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide;2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate;Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester
CBNumber:
CB12657777
Molecular Formula:
C26H30N2O5
Molecular Weight:
450.53
MDL Number:
MFCD22665917
MOL File:
1246213-45-5.mol
MSDS File:
SDS
Last updated:2023-05-16 08:28:57
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Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Properties

Boiling point 583℃
Density 1.198
Flash point 306℃
solubility Acetone, Dichloromethane, Methanol
form Solid
pka 11.60±0.70(Predicted)
color Foamy

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M330548 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 1246213-45-5 50mg $1980 2021-12-16 Buy
Product number Packaging Price Buy
M330548 50mg $1980 Buy

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Chemical Properties,Uses,Production

Uses

N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis.

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester synthesis

1182822-31-6
13721-01-2
1246213-45-5
Synthesis of Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester from 5-amino-2,4-di-tert-butylphenyl methyl carbonate and 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Preparation Products And Raw materials

Raw materials

5-amino-2,4-di-tert-butylphenyl methyl carbonate 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Preparation Products

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10287 55
Jinan Putubio Tech Co., Ltd. +86 (531) 8099-2215 putubio@outlook.com China 1261 55
Jinan elephant international trading co., LTD 13006575422@163.com China 6357 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1946 58
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3069 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1941 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19105 58
Supplier Advantage
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58
Shanghai YuLue Chemical Co., Ltd. 55
Jinan Putubio Tech Co., Ltd. 55
Jinan elephant international trading co., LTD 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Shanghai Moss Medicine Technology Co., Ltd. 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester 2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide Ivacaftor Methylcarbonate 1246213-45-5