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ARV-825

ARV-825 structure

CAS No.: 1818885-28-7

Chemical Name:: ARV-825

Synonyms: AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825;ARV 825;ARV825;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide

CBNumber:: CB13041384

Molecular Formula:: C46H47ClN8O9S

Molecular Weight:: 923.43

MDL Number:: MFCD29472237

MOL File:: 1818885-28-7.mol

Last updated:2023-05-18 11:30:58

Request For Quotation

ARV-825 Properties

Density	1.47±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM) Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form	A crystalline solid
pka	10.74±0.40(Predicted)

SAFETY

Risk and Safety Statements

HS Code	2933998090

ARV-825 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3423	ARV-825 ≥98% (HPLC)	1818885-28-7	5MG	$103	2023-06-20	Buy
Sigma-Aldrich	SML3423	ARV-825 ≥98% (HPLC)	1818885-28-7	25MG	$415	2023-06-20	Buy
Cayman Chemical	21109	ARV-825 ≥98%	1818885-28-7	500μg	$49	2024-03-01	Buy
Cayman Chemical	21109	ARV-825 ≥98%	1818885-28-7	1mg	$92	2024-03-01	Buy
Cayman Chemical	21109	ARV-825 ≥98%	1818885-28-7	5mg	$403	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML3423	5MG	$103	Buy
SML3423	25MG	$415	Buy
21109	500μg	$49	Buy
21109	1mg	$92	Buy
21109	5mg	$403	Buy

ARV-825 Chemical Properties,Uses,Production

Description

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.

Biological Activity

ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.

in vivo

In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)

Target	Value
BRD4 BD2 (Cell-free assay)
BRD4 BD1 (Cell-free assay)	90 nM(Kd)

ARV-825 Preparation Products And Raw materials

Raw materials

Preparation Products

ARV-825 Suppliers

Global( 70)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	6000	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58

Supplier	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Wuhan Fortuna Chemical Co., Ltd	58
InvivoChem	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58

View Lastest Price from ARV-825 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-09-29	ARV-825 1818885-28-7	US $0.00 / mg	1mg	98%min	500mg	WUHAN FORTUNA CHEMICAL CO., LTD
	2020-01-14	ARV-825 1818885-28-7	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

ARV-825
1818885-28-7
US $0.00 / mg
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

ARV-825
1818885-28-7
US $7.00 / KG
99%
Career Henan Chemical Co

1818885-28-7(ARV-825)Related Search:

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- ARCC-4 ARV-771 ARV-471

ARV-825 CS-2252 ARV-825;ARV 825;ARV825 AVR-825 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)- Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide 1818885-28-7 C46H47ClN8O9S