Propargyl-PEG4-thiol
- CAS No.
- 1347750-80-4
- Chemical Name:
- Propargyl-PEG4-thiol
- Synonyms
- SH-PEG4-ALKYNE;HC≡C-CH2-PEG4-SH;CAS_1347750-80-4;ALKYNE-PEG4-THIOL;Propyne-PEG4-thiol;Propargyl-PEG4-thiol;3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
- CBNumber:
- CB13155016
- Molecular Formula:
- C11H20O4S
- Molecular Weight:
- 248.3391
- MDL Number:
- MFCD29764343
- MOL File:
- 1347750-80-4.mol
Propargyl-PEG4-thiol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-23139 | Propargyl-PEG4-thiol 90% | 1347750-80-4 | 100mg | $320 | 2021-12-16 | Buy |
| BroadPharm | BP-23139 | Propargyl-PEG4-thiol 90% | 1347750-80-4 | 500mg | $680 | 2021-12-16 | Buy |
| BroadPharm | BP-23139 | Propargyl-PEG4-thiol 90% | 1347750-80-4 | 1g | $990 | 2021-12-16 | Buy |
| purepeg | 437904 | HC≡C-CH2-PEG4-SH min.95% | 1347750-80-4 | 250mg | $255 | 2021-12-16 | Buy |
Propargyl-PEG4-thiol Chemical Properties,Uses,Production
Description
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
Biological Activity
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
|
Propargyl-PEG4-thiol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
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