BLU-285
- CAS No.
- 1703793-34-3
- Chemical Name:
- BLU-285
- Synonyms
- Avapritinib;BLU-N;CS-2474;CPD1212;BLU-285;abaprotinib;Avapritinib(BLU-285);13C,2H3]-Avapritinib;BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285
- CBNumber:
- CB13171751
- Molecular Formula:
- C26H27FN10
- Molecular Weight:
- 498.56
- MDL Number:
- MFCD31544325
- MOL File:
- 1703793-34-3.mol
| Density | 1.42±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM) |
| form | A crystalline solid |
| pka | 6.96±0.10(Predicted) |
| CAS DataBase Reference | 1703793-34-3 |
| NCI Dictionary of Cancer Terms | avapritinib |
| FDA UNII | 513P80B4YJ |
| NCI Drug Dictionary | avapritinib |
| ATC code | L01EX18 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H332-H334-H340-H350-H360-H373-H412 | |||||||||
| Precautionary statements | P201-P202-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P308+P313-P342+P311-P362+P364-P403-P501c | |||||||||
| NFPA 704 |
|
BLU-285 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22985 | BLU-285 ≥98% | 1703793-34-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 1703793-34-3 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 1703793-34-3 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 1703793-34-3 | 25mg | $618 | 2024-03-01 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 1703793-34-3 | 25mg | $690 | 2021-12-16 | Buy |
BLU-285 Chemical Properties,Uses,Production
Description
BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRαD842V, respectively). It is >150-fold selective for KITD816V and PDGFRαD842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC50s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KITD814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.
Uses
Avapritinib is a medication used for the treatment of tumors due to one specific rare mutation. Avapritinib is a potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor.
BLU-285 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
Related articles
- Synthesis of Avapritinib
- The synthesis of Avapritinib occurs in two steps and requires the involvement of the intermediate Avapritinib Amine Salt.
- Dec 28，2023
