CLORGYLINE HYDROCHLORIDE
- CAS No.
- 17780-75-5
- Chemical Name:
- CLORGYLINE HYDROCHLORIDE
- Synonyms
- Clorgyline HCl;CLORGYLINE HYDROCHLORIDE;Clorgiline (hydrochloride);Clorgyline HCl (M&B 9302, MB9302);N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
- CBNumber:
- CB1445257
- Molecular Formula:
- C13H16Cl3NO
- Molecular Weight:
- 308.63
- MDL Number:
- MFCD00052012
- MOL File:
- 17780-75-5.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O |
| form | A crystalline solid |
| FDA UNII | H38V165133 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UI0675000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
CLORGYLINE HYDROCHLORIDE price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3778 | N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) | 17780-75-5 | 50mg | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | M3778 | N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) | 17780-75-5 | 100mg | $204 | 2024-03-01 | Buy |
| Cayman Chemical | 15925 | Clorgyline (hydrochloride) ≥98% | 17780-75-5 | 10mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15925 | Clorgyline (hydrochloride) ≥98% | 17780-75-5 | 25mg | $56 | 2024-03-01 | Buy |
| Sigma-Aldrich | M3778 | N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride ≥97% (GC) | 17780-75-5 | 500mg | $696 | 2024-03-01 | Buy |
CLORGYLINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-
Uses
Antidepressant;Monoamine oxidase A inhibitor
Uses
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
- in MAO-A biochemical assay
- to study its effects on the transit of serotonin (5-HT) in the human placenta explants
- to study its effects on human prostate cancer cells
Biochem/physiol Actions
MAO-A inhibitor.
References
[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.
CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |