MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
- CAS No.
- 80047-24-1
- Chemical Name:
- MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
- Synonyms
- Win 47338;Milrinone amide;Milrinone USP RC A;Milrinone Impurity Ⅰ;Milrinone Impurity G;Milrinone ImpuritiesA;Milrinone Related CoMpound A;Milrinone USP Related Compound A;6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyr;Milrinone amide (Milrinone impurity)
- CBNumber:
- CB1500512
- Molecular Formula:
- C12H11N3O2
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD09800601
- MOL File:
- 80047-24-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Milrinone Related Compound A United States Pharmacopeia (USP) Reference Standard | 1443919 | 50MG | $1340 |
| 5-DescyanoMilrinone5-Carboxyamide | D289445 | 50mg | $565 |
| 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE 95.00% | CHM0067033 | 1G | $848.93 |
| 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide 98.0% | 4H48-1-5M | 250mg | $120 |
| 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide | 9920AE | 250mg | $177 |
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Properties
| Melting point | >300 °C (decomp) |
|---|---|
| Boiling point | 563.9±50.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Aqueous Acid (Very Slightly), DMSO (Very Slightly, Heated, Sonicated), Methanol |
| form | Solid |
| pka | 8.65±0.10(Predicted) |
| color | Pale Yellow |
| Stability | Hygroscopic |
| Major Application | pharmaceutical |
| InChI | 1S/C12H11N3O2/c1-7-9(8-2-4-14-5-3-8)6-10(11(13)16)12(17)15-7/h2-6H,1H3,(H2,13,16)(H,15,17) |
| InChIKey | SWKVSFPUHCMFJY-UHFFFAOYSA-N |
| SMILES | [nH]1[c](c(cc(c1C)c2ccncc2)C(=O)N)=O |
| FDA UNII | 75E39HK2X2 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| HS Code | 2933790002 |
| Storage Class | 11 - Combustible Solids |
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1443919 | Milrinone Related Compound A United States Pharmacopeia (USP) Reference Standard | 80047-24-1 | 50MG | $1340 | 2026-03-19 | Buy |
| TRC | D289445 | 5-DescyanoMilrinone5-Carboxyamide | 80047-24-1 | 50mg | $565 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0067033 | 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBOXAMIDE 95.00% | 80047-24-1 | 1G | $848.93 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-1-5M | 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide 98.0% | 80047-24-1 | 250mg | $120 | 2021-12-16 | Buy |
| AK Scientific | 9920AE | 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide | 80047-24-1 | 250mg | $177 | 2021-12-16 | Buy |
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Chemical Properties,Uses,Production
Uses
5-Descyano Milrinone 5-Carboxyamide (Milrinone USP Related Compound A) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.
Synthesis
78415-72-2
80047-24-1
General procedure for the synthesis of 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carbonitrile from 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide: Concentrated sulfuric acid (350 μL, 6.3 mmol, 14 equiv) was added to 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2- dihydropyridine-3-carbonitrile (95 mg, 0.450 mmol, 1 eq.) The reaction mixture was heated to 120 °C and maintained for 15 min. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with water, followed by slow addition of concentrated ammonium hydroxide solution to adjust the pH to 10. The precipitate was collected by filtration and washed with an appropriate amount of water, and dried to afford the target product, 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridyl]-5-carboxamide, as a white solid (74 mg, 72% yield).
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 635 - 640
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 11, p. 3021 - 3029
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Preparation Products And Raw materials
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 17714375163 | cfzhang@aikonchem.com | China | 19906 | 55 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 39999 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18421 | 56 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 15250997978 | 1511893459@qq.com | China | 4876 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 | 3193328036@qq.com | China | 6338 | 68 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9629 | 60 |
80047-24-1(MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE))Related Search:
1of4
