ChemicalBook >> CAS DataBase List >>E1R
E1R
- CAS No.
- 1301211-78-8
- Chemical Name:
- E1R
- Synonyms
- E1R;E1R,E-1R;1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-
- CBNumber:
- CB15821375
- Molecular Formula:
- C13H16N2O2
- Molecular Weight:
- 232.28
- MDL Number:
- MFCD32067912
- MOL File:
- 1301211-78-8.mol
Last updated:2023-05-21 10:59:17
E1R price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0065560 | E1R 99.28% | 1301211-78-8 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0065560 | E1R 99.28% | 1301211-78-8 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0065560 | E1R 99.28% | 1301211-78-8 | 25mg | $990 | 2021-12-16 | Buy |
| ChemScene | CS-0065560 | E1R 99.28% | 1301211-78-8 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0065560 | E1R 99.28% | 1301211-78-8 | 100mg | $2250 | 2021-12-16 | Buy |
E1R Chemical Properties,Uses,Production
Biological Activity
E1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) with cognitive enhancing effects.
in vitro
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
in vivo
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered ip 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice .
| Animal Model: | Male ICR and Balb/c mice weighed 23-25 g |
| Dosage: | 0.1, 1 and 10 mg/kg |
| Administration: | Administered ip 60 min before the training session |
| Result: | Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group. |
E1R Preparation Products And Raw materials
Raw materials
Preparation Products
E1R Suppliers
Global( 9)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
E1R
1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-
E1R,E-1R
1301211-78-8