4-IODO-6-PHENYLPYRIMIDINE
- CAS No.
- 41270-96-6
- Chemical Name:
- 4-IODO-6-PHENYLPYRIMIDINE
- Synonyms
- 4-IPP;MIF Antagonist III, 4-IPP;4-IODO-6-PHENYLPYRIMIDINE;Pyrimidine, 4-iodo-6-phenyl-;4-IPP (4-Iodo-6-phenylpyrimidine);MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem;Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
- CBNumber:
- CB1686643
- Molecular Formula:
- C10H7IN2
- Molecular Weight:
- 282.08
- MDL Number:
- MFCD00234609
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
4-IODO-6-PHENYLPYRIMIDINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0472 | 4-IPP ≥97% (HPLC) | 41270-96-6 | 5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | 475846 | MIF Antagonist III, 4-IPP | 41270-96-6 | 10mg | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0472 | 4-IPP ≥97% (HPLC) | 41270-96-6 | 25mg | $631 | 2024-03-01 | Buy |
| Tocris | 3429 | 4-IPP ≥98%(HPLC) | 41270-96-6 | 50 | $688 | 2021-12-16 | Buy |
| Tocris | 3429 | 4-IPP ≥98%(HPLC) | 41270-96-6 | 10 | $163 | 2021-12-16 | Buy |
4-IODO-6-PHENYLPYRIMIDINE Chemical Properties,Uses,Production
Uses
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.
Definition
ChEBI: 4-iodo-6-phenylpyrimidine is a member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. It has a role as a macrophage migration inhibitory factor inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrimidines, a biaryl and an organoiodine compound.
Biological Activity
Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .
Biochem/physiol Actions
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
storage
Store at +4°C
4-IODO-6-PHENYLPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-IODO-6-PHENYLPYRIMIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Struchem Co., Ltd. | 0512-0512-63009836 15365350169 | helen@struchem.com | China | 3989 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |