ChemicalBook >> CAS DataBase List >>S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA structure

CAS No.: 37686-84-3

Chemical Name:: S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

Synonyms: TDHL;dironyl;Teluron;tergurid;terguride;S(+)-TERGURIDE;R-(+)-TERGURIDE;TRANS-DIHYDROLISURIDE;(5R,8S,10R)-Terguride;9,10a-Dihydrolisuride

CBNumber:: CB1710346

Molecular Formula:: C20H28N4O

Molecular Weight:: 340.46

MDL Number:: MFCD00242729

MOL File:: 37686-84-3.mol

MSDS File:: SDS

Last updated:2023-05-04 17:34:38

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S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Properties

Melting point	203-204° (dec); mp 205-207° (dec) (Cerny)
alpha	D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine)
Boiling point	476.25°C (rough estimate)
Density	1.1056 (rough estimate)
refractive index	1.6620 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble
form	solid
pka	13.60±0.20(Predicted)
color	white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
FDA UNII	21OJT43Q88
ATC code	G02CB06

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H331-H311
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501
Hazard Codes	T
Risk Statements	23/24/25
Safety Statements	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	YS9378700
Toxicity	LD50 oral in rat: 100mg/kg

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Medical Isotopes, Inc.	39958	trans-DihydroLisuride	37686-84-3	10mg	$2800	2021-12-16	Buy
American Custom Chemicals Corporation	API0004355	TERGURIDE 95.00%	37686-84-3	10MG	$2804.55	2021-12-16	Buy
Alichem	37686843	1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea	37686-84-3	1g	$988.8	2021-12-16	Buy
Crysdot	CD11133101	1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 95+%	37686-84-3	1g	$1186	2021-12-16	Buy

Product number	Packaging	Price	Buy
39958	10mg	$2800	Buy
API0004355	10MG	$2804.55	Buy
37686843	1g	$988.8	Buy
CD11133101	1g	$1186	Buy

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Chemical Properties,Uses,Production

Description

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3

Uses

An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Definition

ChEBI: Terguride is an organic molecular entity.

References

1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507 2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215 3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Preparation Products And Raw materials

Raw materials

Preparation Products

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Suppliers

Global( 32)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30231	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Aikon International Limited	025-58859352 18068836627	sales01@aikonchem.com	China	15084	58
Hunan chemfish Scientific co.,ltd	0731-+8619313119731 18229978283	sales@chemfish.com	China	4584	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24641	58

Supplier	Advantage
Career Henan Chemica Co	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
	69
LGM Pharma	70
Chemsky (shanghai) International Co.,Ltd	60
Aikon International Limited	58
Hunan chemfish Scientific co.,ltd	58
Energy Chemical	58
TargetMol Chemicals Inc.	58

37686-84-3(S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA)Related Search:

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Bromocriptine n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)urea(z)-2-butenedioat R)-3-PHENYL PIPERIDINE 3-AMINOPIPERIDINE (S)-3-Aminopiperidine

S-(-)-LISURIDE S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA 1H-Indole, 4-(3-piperidinyl)-, (R)- 3-AMINO-1-METHYL-PIPERIDINE 2 HCL α-Ethyltryptamine

Proterguride

1of4

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA S(+)-TERGURIDE S(+)-TERGURIDE (5R, 8S, 10R) R-(+)-TERGURIDE TRANS-DIHYDROLISURIDE 1-((5r,8s,10r)-6-methyl-8-ergolinyl)-3,3-diethylurea 9,10-alpha-dihydrolisuride N,N-Diethyl-N'-[(8α)-6-Methylergolin-8-yl]urea dironyl n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)-ure tergurid terguride s(+)-n,n-diethyl-n'([8α]-6-methylergolin-8-yl)urea (+)-(5R,8S,10R)-Terguride (5R,8S,10R)-Terguride 6-Methyl-8a-(diethylcarbamoylamino)ergoline 9,10a-Dihydrolisuride Ergoline, urea deriv. Indolo[4,3-fg]quinoline, urea deriv. N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea TDHL Urea, N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- (9CI) S(+)-N,N-Diethyl-Nμ([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R) 1,1-Diethyl-3-(6-methylergolin-8α-yl)urea Teluron 6-Methyl-8α-(diethylcarbaMoylaMino)ergoline 9,10α-Dihydrolisuride N,N-Diethyl-N'-(D-6-Methyl-10α-isoergolin-8-yl)urea Urea, N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]- 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea Terguride, Partial D2 agonist 37686-84-3 Agonists Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals API