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ChemicalBook >> CAS DataBase List >>S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Structure
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA structure
CAS No.
37686-84-3
Chemical Name:
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
Synonyms
TDHL;dironyl;Teluron;tergurid;terguride;S(+)-TERGURIDE;R-(+)-TERGURIDE;TRANS-DIHYDROLISURIDE;(5R,8S,10R)-Terguride;9,10a-Dihydrolisuride
CBNumber:
CB1710346
Molecular Formula:
C20H28N4O
Molecular Weight:
340.46
MDL Number:
MFCD00242729
MOL File:
37686-84-3.mol
MSDS File:
SDS
Last updated:2026-01-10 21:27:14
Product description Number Pack Size Price
trans-DihydroLisuride 39958 10mg $2800
TERGURIDE 95.00% API0004355 10MG $2804.55
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 37686843 1g $988.8
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 95+% CD11133101 1g $1186
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S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Properties

Melting point 203-204° (dec); mp 205-207° (dec) (Cerny)
alpha D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine)
Boiling point 476.25°C (rough estimate)
Density 1.1056 (rough estimate)
refractive index 1.6620 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
form solid
pka 13.60±0.20(Predicted)
color white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey JOAHPSVPXZTVEP-IHMLPVBLNA-N
SMILES C12=C3C=CC=C1[C@@]1([H])C[C@@H](CN(C)[C@]1([H])CC2=CN3)NC(=O)N(CC)CC |&1:6,9,13,r|
FDA UNII 21OJT43Q88
ATC code G02CB06

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H331-H311
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  YS9378700
Toxicity LD50 oral in rat: 100mg/kg

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Medical Isotopes, Inc. 39958 trans-DihydroLisuride 37686-84-3 10mg $2800 2021-12-16 Buy
American Custom Chemicals Corporation API0004355 TERGURIDE 95.00% 37686-84-3 10MG $2804.55 2021-12-16 Buy
Alichem 37686843 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 37686-84-3 1g $988.8 2021-12-16 Buy
Crysdot CD11133101 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 95+% 37686-84-3 1g $1186 2021-12-16 Buy
Product number Packaging Price Buy
39958 10mg $2800 Buy
API0004355 10MG $2804.55 Buy
37686843 1g $988.8 Buy
CD11133101 1g $1186 Buy

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Chemical Properties,Uses,Production

Description

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3

Uses

An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Definition

ChEBI: Terguride is an organic molecular entity.

in vivo

TDHL abolished 5-HT-induced pulmonary vasoconstriction. Chronic terguride treatment prevented dose-dependently the development and progression of MCT-induced PAH in rats[1]. In reserpinized rats, terguride at 0.03 mg/kg, p.o. significantly reduces the serum prolactin (PRL) level. In rats bearing estrogen-induced pituitary prolactinoma, chronic terguride induces shrinkage of the prolactinoma as well as reduction of the high serum PRL level. In lactating rats, terguride (1.0 mg/kg, s.c.) reduces milk production in the mammary gland[2].

References

[1] TETSUO AKAI MS, PHD. Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys[J]. Annals of Neurology, 1993, 33 5: 507-511. DOI:10.1002/ana.410330515
[2] IB V. KLEWE . Recruitment of β-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling[J]. Neuropharmacology, 2008, 54 8: Pages 1215-1222. DOI:10.1016/j.neuropharm.2008.03.015
[3] R DUMITRASCU. Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.[J]. European Respiratory Journal, 2011, 37 5: 1104-1118. DOI:10.1183/09031936.00126010

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Preparation Products And Raw materials

Raw materials

Preparation Products

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Qiantai Pharma Co., Ltd.
+8615862471140 richardchan@bright-gene.com China 84 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30228 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2123 70
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15402 60
Aikon International Limited 025-58859352 18068836627 sales01@aikonchem.com China 15082 58
Hunan chemfish Scientific co.,ltd 85567275 15528049369 sales06@chemfish.com China 4983 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
Supplier Advantage
Chongqing Qiantai Pharma Co., Ltd.
58
Career Henan Chemica Co 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
LGM Pharma 70
Chemsky (shanghai) International Co.,Ltd 60
Aikon International Limited 58
Hunan chemfish Scientific co.,ltd 58
Energy Chemical 58

37686-84-3(S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA)Related Search:

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Bromocriptine n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)urea(z)-2-butenedioat R)-3-PHENYL PIPERIDINE 3-AMINOPIPERIDINE (S)-3-Aminopiperidine
S-(-)-LISURIDE S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA 1H-Indole, 4-(3-piperidinyl)-, (R)- 3-AMINO-1-METHYL-PIPERIDINE 2 HCL α-Ethyltryptamine
Proterguride

1of4

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA S(+)-TERGURIDE S(+)-TERGURIDE (5R, 8S, 10R) R-(+)-TERGURIDE TRANS-DIHYDROLISURIDE 1-((5r,8s,10r)-6-methyl-8-ergolinyl)-3,3-diethylurea 9,10-alpha-dihydrolisuride N,N-Diethyl-N'-[(8α)-6-Methylergolin-8-yl]urea dironyl n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)-ure tergurid terguride s(+)-n,n-diethyl-n'([8α]-6-methylergolin-8-yl)urea (+)-(5R,8S,10R)-Terguride (5R,8S,10R)-Terguride 6-Methyl-8a-(diethylcarbamoylamino)ergoline 9,10a-Dihydrolisuride Ergoline, urea deriv. Indolo[4,3-fg]quinoline, urea deriv. N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea TDHL Urea, N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- (9CI) S(+)-N,N-Diethyl-Nμ([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R) 1,1-Diethyl-3-(6-methylergolin-8α-yl)urea Teluron 6-Methyl-8α-(diethylcarbaMoylaMino)ergoline 9,10α-Dihydrolisuride N,N-Diethyl-N'-(D-6-Methyl-10α-isoergolin-8-yl)urea Urea, N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]- 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea Terguride, Partial D2 agonist 37686-84-3 Agonists Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals API