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ATPA

ATPA structure

CAS No.: 140158-50-5

Chemical Name:: ATPA

Synonyms: ATPA;(R,S)-ATPA;ATP synthase α chain;alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate;(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID;2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid;4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-

CBNumber:: CB1719521

Molecular Formula:: C10H16N2O4

Molecular Weight:: 228.24

MDL Number:: MFCD01860864

MOL File:: 140158-50-5.mol

Last updated:2023-07-02 08:28:07

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ATPA Properties

Density	1.263±0.06 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	DMSO: 10 mg/mL
pka	2.15±0.10(Predicted)
form	solid
color	white

SAFETY

Risk and Safety Statements

WGK Germany	3

ATPA price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	1107	ATPA ≥98%(HPLC)	140158-50-5	10	$227	2021-12-16	Buy
Tocris	1107	ATPA ≥98%(HPLC)	140158-50-5	50	$936	2021-12-16	Buy
Usbiological	254690	ATPA	140158-50-5	10mg	$480	2021-12-16	Buy
TRC	A790535	(R,S)-ATPA	140158-50-5	1mg	$130	2021-12-16	Buy
ChemScene	CS-0021056	ATPA >98.0%	140158-50-5	10mg	$685	2021-12-16	Buy

Product number	Packaging	Price	Buy
1107	10	$227	Buy
1107	50	$936	Buy
254690	10mg	$480	Buy
A790535	1mg	$130	Buy
CS-0021056	10mg	$685	Buy

ATPA Chemical Properties,Uses,Production

Uses

(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.

Definition

ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.

Biological Activity

A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .

storage

Desiccate at +4°C

ATPA synthesis

Synthesis of ATPA from Propanedioic acid, 2-(acetylamino)-2-[[5-(1,1-dimethylethyl)-3-methoxy-4-isoxazolyl]methyl]-, 1,3-diethyl ester

ATPA Preparation Products And Raw materials

Raw materials

Preparation Products

ATPA Suppliers

Global( 26)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
Kaifeng Mingren Pharmaceutical Co.,LTD	0371-65741762	sales@hasunny.com	China	2380	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
EMMX Biotechnology LLC	60
MedBioPharmaceutical Technology Inc	58
Energy Chemical	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Kaifeng Mingren Pharmaceutical Co.,LTD	58

140158-50-5(ATPA)Related Search:

ATPA ( Z )-2-(2-AMINOTHIAZOL-4-YL)-2-PENTENOIC ACID (ATPA) ATPA ((RS)-2-AMINO-3-(3-HYDROXY-5-TERT-B,(R,S)-ATPA,ATPA (R)-ATPA, >97% (RS)-AMPA

CHEMBRDG-BB 4009738 (R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID 2-ISOXAZOL-4-YL-ETHYLAMINE ATPA (R)-ATPA

(S)-ATPA

1of3

(R,S)-ATPA (RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID (R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID (RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID (RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID ATPA alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate ATP synthase α chain 4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo- 2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid 140158-50-5 Cell Biology Cell Signaling and Neuroscience BioChemical Ligand-Gated Ion Channels Ion Channels Ionotropic Glutamate Receptor Modulators