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4-Amino-L-phenylalanine

4-Amino-L-phenylalanine Structure
4-Amino-L-phenylalanine structure
CAS No.
943-80-6
Chemical Name:
4-Amino-L-phenylalanine
Synonyms
4-Amino-L;4-Amino-Phe;L-4-AMINOPHE;4-Amino-L-Phe;L-4-NH2-Phe-OH;4-Amino-Phe-OH;H-PHE(4-NH2)-OH;H-PHE(4'-NH2)-OH;Aminophenyalanine;H-L-Phe(4-NH2)-OH
CBNumber:
CB1722156
Molecular Formula:
C9H12N2O2
Molecular Weight:
180.2
MDL Number:
MFCD00069927
MOL File:
943-80-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:53
Product description Number Pack Size Price
p-Amino-L-phenylalanine A622376 2.5g $145
4-Amino-L-phenylalanine 99+% 232813 1g $170
4-AMINO-L-PHENYL ALANINE 95.00% AAA0000765 1G $159.71
H-L-Phe(4-NH2)-OH*hydrate HAA7050 5G $162
H-Phe(4-NH2)-OH 181603 25g $330
More product size
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4-Amino-L-phenylalanine Properties

Melting point 265 °C (decomp)
Boiling point 383.5±32.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol (Slightly, Sonicated), Water (Slightly, Sonicated)
pka 2.14±0.10(Predicted)
form Solid
color Pale Beige to Beige
Water Solubility Soluble in water.
Sensitive Air Sensitive
CAS DataBase Reference 943-80-6(CAS DataBase Reference)
FDA UNII 1567B560CH

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  2922498590
NFPA 704
0
0 0

4-Amino-L-phenylalanine price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A622376 p-Amino-L-phenylalanine 943-80-6 2.5g $145 2021-12-16 Buy
Usbiological 232813 4-Amino-L-phenylalanine 99+% 943-80-6 1g $170 2021-12-16 Buy
American Custom Chemicals Corporation AAA0000765 4-AMINO-L-PHENYL ALANINE 95.00% 943-80-6 1G $159.71 2021-12-16 Buy
Iris Biotech GmbH HAA7050 H-L-Phe(4-NH2)-OH*hydrate 943-80-6 5G $162 2021-12-16 Buy
chempep 181603 H-Phe(4-NH2)-OH 943-80-6 25g $330 2021-12-16 Buy
Product number Packaging Price Buy
A622376 2.5g $145 Buy
232813 1g $170 Buy
AAA0000765 1G $159.71 Buy
HAA7050 5G $162 Buy
181603 25g $330 Buy

4-Amino-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline powder

Uses

It finds its application in the purification of peptide synthetases involved in pristinamycin I biosynthesis.

Definition

ChEBI: 4-amino-L-phenylalanine is the L-enantiomer of 4-aminophenylalanine. It is an enantiomer of a 4-amino-D-phenylalanine. It is a tautomer of a 4-amino-L-phenylalanine zwitterion.

Synthesis

4-Nitro-3-phenyl-L-alanine

949-99-5

4-Amino-L-phenylalanine

943-80-6

A mixed solution of concentrated HNO3 (60%) and concentrated H2SO4 (1.4:1.1 v/v) was prepared and cooled to 10°C. A portion of the mixed solution (3.5 mL) was slowly added dropwise to a solution of L-phenylalanine (4.139 g, 25.1 mmol) in H2SO4 (98%, 12.5 mL) with stirring. The reaction mixture was kept stirred at 10 °C for 2.5 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted with NH4OH to 5. The resulting light yellow precipitate was collected by filtration, washed sequentially with a small amount of water and CH3CN, and dried to give 4-nitro-L-phenylalanine as a yellow powder (4.748 g, 90% yield). 4-Nitro-L-phenylalanine (2.006 g, 9.54 mmol) was suspended in water (35 mL), 0.2 g of 5% palladium-barium sulfate catalyst was added, and the hydrogenation reaction was carried out for 3 h at room temperature. The reaction solution was filtered through a diatomaceous earth pad and the filtrate was concentrated to give a light brown residue. The residue was washed with CH3CN to give a light brown solid (1.460 g, 85% yield) which was used directly in the next step of the reaction. 4-Amino-L-phenylalanine derivative (0.060 g, 0.33 mmol) was dissolved in 6N HCl (4 mL) and aqueous sodium nitrate solution (0.030 g/0.5 mL) was slowly added at 0 °C. The reaction mixture was stirred at the same temperature for 40 min and then diluted with 6N HCl (0.25 mL). Subsequently, aqueous sodium azide solution (0.033 g/0.75 mL) was added at 0 °C. The reaction mixture was stirred at 0 °C for 5 min and then warmed up to room temperature to continue the reaction for 1 h. The reaction mixture was then concentrated and the reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was concentrated and the residue was reprecipitated by CH3CN to give a pure colorless amorphous solid (0.0435 g, 64% yield). The analytical and spectroscopic data of the product were in agreement with literature reports [10].

IC 50

Human Endogenous Metabolite

References

[1] Letters in Drug Design and Discovery, 2015, vol. 12, # 6, p. 466 - 470
[2] Molecules, 2013, vol. 18, # 7, p. 8393 - 8401
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 80,83
[4] Chemistry Letters, 1998, # 7, p. 704 - 706
[5] Chemistry Letters, 1998, # 6, p. 537 - 538

4-Amino-L-phenylalanine Preparation Products And Raw materials

Raw materials

4-Nitro-3-phenyl-L-alanine Hydrogen

Preparation Products

BOC-TYR(3,5-BR2)-OH

4-Amino-L-phenylalanine Suppliers

Global( 237)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3996 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
GL Biochem(Binhai) Ltd. 		+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9541 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
GenicBio Limited 		58
career henan chemical co 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
GL Biochem(Binhai) Ltd. 		58
Finetech Industry Limited 		58

View Lastest Price from 4-Amino-L-phenylalanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-L-phenylalanine pictures 2025-12-24 4-Amino-L-phenylalanine
943-80-6
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
4-Amino-L-phenylalanine pictures 2021-07-13 4-Amino-L-phenylalanine
943-80-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
4-Amino-L-phenylalanine pictures 2019-07-06 4-Amino-L-phenylalanine
943-80-6
 US $8.00 / kg 1kg 99% 10MT Career Henan Chemical Co

4-Amino-L-phenylalanine Spectrum

4-Amino-L-phenylalanine(943-80-6)1HNMR

943-80-6(4-Amino-L-phenylalanine)Related Search:

Phenprobamate ALTRENOGEST N-(tert-Butoxycarbonyl)-L-phenylalanine Betaine D-Phenylalanine
L-Phenylalanine Glycine 4-Methylphenyl-L-alanine L-4-AMINOMETHYLPHE L-4-CARBAMOYLPHE
L-4-BENZOYLPHENYLALANINE L-4-Iodophenylalanine L-4-Chlorophenylalanine L-PHE(4-COCH3) L-4-Fluorophenylalanine
O-METHYL-L-TYROSINE 4-Nitro-3-phenyl-L-alanine 4-Bromo-L-phenylalanine

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4-Amino-Phe L-4-NH2-Phe-OH 4-AMINO-L-PHENYLALANINE 99% Aminophenyalanine p-Aminophenylalanine (2S)-2-amino-3-(4-aminophenyl)propionic acid (2S)-2-azanyl-3-(4-azanylphenyl)propanoic acid 4-Amino-L-phenylalan L-4-NH2-Phe-OH 4-AMino-L-Phenylalanine para-Aminophenylalanine Phenylalanine, 4-amino- L-4-AMINOPHE L-4-AMINOPHENYLALANINE L-4-AMINOPHENYLALANINE DIHYDROCHLORIDE H-PHE(P-NH2)-OH 2HCL H-PHE(4-NH2)-OH H-PHE(4-NH2)-OH 2HCL H-P-AMINO-L-PHE-OH L-P-AMINOPHENYLALANINE 2HCL 4-AMINO-PHENYLALANINE 4-AMINO-L-PHENYLALANINE (S)-2-AMINO-3-(4-AMINOPHENYL)PROPANOIC ACID P-AMINO-L-PHENYLALANINE H-PHE(4'-NH2)-OH 4-Amino-L-phenylalanine≥ 99% (HPLC) π-Amino-L-phenylalanine 4-Amino-Phe-OH (2R)-2-amino-3-(4-aminophenyl)propanoic acid 4-amino-pyenylalanine 4-Amino-L-phenylalanine,95% 4-Amino-L-phenylalanine USP/EP/BP L-2-Amino-3-(4-amino-phenyl)-propionic acid H-L-Phe(4-NH2)-OH 4-Amino-L-Phe 4-Amino-L L-Phenylalanine, 4-amino- Melphalan Impurity 28 943-80-6 C9H12N2O2 Carboxylic acid Amines Phenylalanine [Phe, F] a-amino Phenylalanine analogs and other aromatic alpha amino acids Unusual Amino Acids Amino Acids 13C, 2H, 15N Chiral Compound Amino Acids