TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
- CAS No.
- 916421-36-8
- Chemical Name:
- TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE
- Synonyms
- 4-(1-Boc-3-azetidinyl)aniline;TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE;3- (4-aminophenyl) azacyclobutane-1-tert-butyl carboxylate;3- (4-aminophenyl) azacyclobutane-1-carboxylic acid tert butyl ester;1-Azetidinecarboxylic acid, 3-(4-aminophenyl)-, 1,1-dimethylethyl ester;tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate , tert-Butyl 3-(4-aminophenyl)azetidine-1-carboxylate
- CBNumber:
- CB1820863
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MDL Number:
- MFCD08751348
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| TERT-BUTYL-3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE 95.00% | CHM0371124 | 5MG | $503.1 |
| Tert-butyl3-(4-aminophenyl)azetidine-1-carboxylate | 2107DN | 5g | $2085 |
| tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate 95+% | CD11017111 | 5g | $2475 |
| tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate 95+% | CD11017111 | 10g | $3465 |
| tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate | 916421368 | 5g | $3651.5 |
| More product size | |||
TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0371124 | TERT-BUTYL-3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE 95.00% | 916421-36-8 | 5MG | $503.1 | 2021-12-16 | Buy |
| AK Scientific | 2107DN | Tert-butyl3-(4-aminophenyl)azetidine-1-carboxylate | 916421-36-8 | 5g | $2085 | 2021-12-16 | Buy |
| Crysdot | CD11017111 | tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate 95+% | 916421-36-8 | 5g | $2475 | 2021-12-16 | Buy |
| Crysdot | CD11017111 | tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate 95+% | 916421-36-8 | 10g | $3465 | 2021-12-16 | Buy |
| Alichem | 916421368 | tert-Butyl3-(4-aminophenyl)azetidine-1-carboxylate | 916421-36-8 | 5g | $3651.5 | 2021-12-16 | Buy |
TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Chemical Properties,Uses,Production
Synthesis
883901-62-0
916421-36-8
General procedure for the synthesis of tert-butyl 3-(4-aminophenyl)azetidine-1-carboxylate from tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate: 10% Pd/C (0.320 g) and 3-(4-nitrophenyl)tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate (16) (2.14 g, 7.68 mmol) were mixed in a EtOAc (16 mL) solution was suspended under hydrogen atmosphere and the reaction was stirred for 18 hours. Subsequently, 10% Pd/C (1.00 g) was added supplementally and stirring was continued for 20 hours. Upon completion of the reaction, the mixture was filtered through a Celite pad, the filter cake was washed with EtOAc, and the filtrates were combined and concentrated in vacuo to afford the title compound 17 as a light yellow to cream solid (1.80 g, 94% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 7.12 (d, J = 8.3 Hz, 2H), 6.69 (dd, J = 6.5, 1.9 Hz, 2H), 4.29 (t, J = 8.7 Hz, 2H), 3.93 (dd, J = 8.4, 6.1 Hz, 2H), 3.65 (brs, 2H), 1.55- 1.68 (m, 1H), 1.48 (s, 9H).LCMS analysis: retention time 4.964 min; m/z 249 [M + H]+.
References
[1] Patent: WO2014/26243, 2014, A1. Location in patent: Page/Page column 89
[2] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 133; 134
TERT-BUTYL 3-(4-AMINOPHENYL)AZETIDINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3767 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | sales@accelachem.com | China | 11032 | 64 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
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