ChemicalBook >> CAS DataBase List >>5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- CAS No.
- 137206-97-4
- Chemical Name:
- 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- Synonyms
- DPMQ;DMPQ2HCl;DMPQ DIHYDROCHLORIDE;5,7-dimethoxy-3-pyridin-4-ylquinoline;5,7-dimethoxy-3-(4-pyridinyl)quinoline;Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-;5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE;5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride
- CBNumber:
- CB2106454
- Molecular Formula:
- C16H14N2O2
- Molecular Weight:
- 266.29
- MDL Number:
- MFCD02262123
- MOL File:
- 137206-97-4.mol
Last updated:2023-04-23 13:52:06
| Boiling point | 441.3±40.0 °C(Predicted) |
|---|---|
| Density | 1.192±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml). |
| form | solid |
| pka | 3.58±0.38(Predicted) |
| color | Yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1222 | DMPQ dihydrochloride ≥99%(HPLC) | 137206-97-4 | 10 | $149 | 2021-12-16 | Buy |
| Tocris | 1222 | DMPQ dihydrochloride ≥99%(HPLC) | 137206-97-4 | 50 | $567 | 2021-12-16 | Buy |
| Usbiological | 255176 | DMPQ dihydrochloride | 137206-97-4 | 10mg | $403 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000096 | DMPQ DIHYDROCHLORIDE 95.00% | 137206-97-4 | 10MG | $665.81 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000096 | DMPQ DIHYDROCHLORIDE 95.00% | 137206-97-4 | 1MG | $135.45 | 2021-12-16 | Buy |
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Uses
DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).
Biological Activity
A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
References
1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Suppliers
Global( 34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| SynAsst Chemical. | 021-60343070 | China | 12742 | 55 | |
| Synchem OHG | +49 5662 408730 | info@synchem.de | Germany | 4708 | 70 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Supplier | Advantage |
|---|---|
| Alchem Pharmtech,Inc. | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| SynAsst Chemical. | 55 |
| Synchem OHG | 70 |
| EMMX Biotechnology LLC | 60 |
137206-97-4(5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE)Related Search:
DMPQ DIHYDROCHLORIDE
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
DMPQ2HCl
Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-
5,7-dimethoxy-3-(4-pyridinyl)quinoline
5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride
5,7-dimethoxy-3-pyridin-4-ylquinoline
DPMQ
137206-97-4
C16H14N2O22HCl
Protein Kinase