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ChemicalBook >> CAS DataBase List >>(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Structure
(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol structure
CAS No.
156722-18-8
Chemical Name:
(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
Synonyms
CS-906;PST2238;17-triol;AC1L4BGU;Rostafuroxin;CHEMBL2068971;SureCN1716210;PST 2238, >=98%;UNII-P848LCX62B;PST2238,Rostafuroxin
CBNumber:
CB21253997
Molecular Formula:
C23H34O4
Molecular Weight:
374.51
MDL Number:
MFCD00927279
MOL File:
156722-18-8.mol
Last updated:2023-06-30 15:45:59
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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Properties

Boiling point 451.3±45.0 °C(Predicted)
Density 1.226±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥12.05 mg/mL in DMSO
form solid
pka 14.02±0.70(Predicted)
FDA UNII P848LCX62B

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21282 Rostafuroxin ≥98% 156722-18-8 1mg $32 2024-03-01 Buy
Cayman Chemical 21282 Rostafuroxin ≥98% 156722-18-8 5mg $93 2024-03-01 Buy
Cayman Chemical 21282 Rostafuroxin ≥98% 156722-18-8 10mg $169 2024-03-01 Buy
Cayman Chemical 21282 Rostafuroxin ≥98% 156722-18-8 25mg $381 2024-03-01 Buy
Tocris 5315 Rostafuroxin ≥98%(HPLC) 156722-18-8 10 $210 2021-12-16 Buy
Product number Packaging Price Buy
21282 1mg $32 Buy
21282 5mg $93 Buy
21282 10mg $169 Buy
21282 25mg $381 Buy
5315 10 $210 Buy

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Chemical Properties,Uses,Production

Description

Rostafuroxin potently inhibits binding of endogenous ouabain to the Na+/K+ ATPase (IC50 = 1.7 μM) through the Src-epidermal growth factor receptor (EGFR)-dependent signaling pathway. This blocks the ouabain-dependent increase in Na+/K+ ATPase activity. In cultured renal cells where the Na+/K+ ATPase is upregulated or has increased activity, rostafuroxin normalizes mRNA levels and Na+/K+ ATPase activity. At very low doses (1 and 10 μg/kg for 5-6 weeks) in Milan-hypertensive rats, it decreased the development of hypertension. In a Phase II clinical study, rostafuroxin did not reduce blood pressure in human patients at doses of 0.05-5.0 mg/d.

Uses

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol is used as a receptor blocker in the treatment of hypertension.

in vitro

at molecular level, in the kidney, rostafuroxin antagonizes eo by triggering of the src-epidermal growth factor receptor (egfr)-dependent signaling pathway leading to renal na+-k+ pump, and erk tyrosine phosphorylation and activation. in the vasculature, it normalizes the increased myogenic tone caused by nanomolar ouabain [1].

in vivo

rostafuroxin reduces blood pressure without affecting heart rate, and restores the normal activity of the renal na+-k+-atpase in mhs rats when orally treated at doses from 1 to 100 μg/kg/day. similarly, nua rats have their blood pressure normalized by rostafuroxin [1].

IC 50

2 μm for na+-k+-atpase

storage

Store at +4°C

References

[1] ferrari p, ferrandi m, valentini g, bianchi g. rostafuroxin: an ouabain antagonist that corrects renal and vascular na+-k+-atpase alterations in ouabain and adducin-dependent hypertension. am j physiol regul integr comp physiol. 2006 mar;290(3):r529-35.

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Preparation Products And Raw materials

Raw materials

Preparation Products

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Suppliers

Global( 78)Suppliers
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BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
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Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rostafuroxin pictures 2021-07-13 Rostafuroxin
156722-18-8
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Rostafuroxin pictures 2021-07-10 Rostafuroxin
156722-18-8
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Rostafuroxin pictures
  • Rostafuroxin
    156722-18-8
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Rostafuroxin pictures
  • Rostafuroxin
    156722-18-8
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Spectrum

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol(156722-18-8)1HNMR
(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Rostafuroxin PST2238 (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST-2238) (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin PST2284 (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) Rostafuroxin (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol PST 2238, >=98% CS-906 17-β-(3-furyl)-5-β-androstane-3-β, 14-β, 17-α-triol 17-(3-Furyl)-5beta-androstane-3 17-triol AC1L4BGU CHEMBL2068971 PST 2238; PST-2238; AC1L4BGU; SURECN1716210; UNII-P848LCX62B; 17-(3-FURYL)-5BETA-ANDROSTANE-3;14;17-TRIOL; CHEMBL2068971; 156722-18-8 SureCN1716210 UNII-P848LCX62B PST2238,Rostafuroxin 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)- 24-Norchola-20,22-diene-3,14,17-triol,21,23-epoxy-, (3b,5b,14b)- Rostafuroxin,ATP1A1,RSV,PST-2238,Respiratory syncytial virus,Na+/K+ ATPase,phosphorylation,inhibit,PST2238,Tyr845,Sodium potassium pump,EGFR,antihypertensive,RSV-GFP,Inhibitor,digitoxigenin,Ouabain (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol (3S,5R,8R,9S,10S,13S,14S,17S)-17-(Furan-3-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol 156722-18-8 Inhibitors