kopsine
- CAS No.
- 559-48-8
- Chemical Name:
- kopsine
- Synonyms
- kopsine;3-Hydroxy-22-oxokopsan-1-carboxylic acid methyl ester;6H,13aH-3a,5a-Ethano-5,11-methano-1H-indolizino[8,1-cd]carbazole-6-carboxylic acid, 2,3,4,5,11,12-hexahydro-5-hydroxy-14-oxo-, methyl ester, (3aR,5S,5aS,10bR,11R,13aS)- (9CI)
- CBNumber:
- CB21480539
- Molecular Formula:
- C22H24N2O4
- Molecular Weight:
- 380.44
- MDL Number:
- MOL File:
- 559-48-8.mol
Last updated:2022-12-21 16:56:50
| Melting point | 220°C (dec.). |
|---|---|
| alpha | D27 -14.3 ± 1° (c = 2 in chloroform) |
| FDA UNII | 9999HLB81M |
kopsine Chemical Properties,Uses,Production
Description
The major constituent of Kopsia !ruticosa, this base has [α]D - 17.5° (c 2.15, CHC13). It forms a series of crystalline salts and derivatives, e.g. the aurichloride, m.p. 203-5°C (dec.); perchlorate, m.p. 284°C (dec.); picrate, m.p. 230°C (dec.) and methiodide, m.p. 200°C (dec.). It may be reduced to the dihydro derivative which has m.p. 218°C. When fused with NaOH the alkaloid furnishes 2- methylindole and 2-indole-2-carboxylic acid.
References
Bhattacharya et al., 1. Amer. Chem. Soc., 71,3370 (1949)
Spiteller et al., Naturwiss., 49, 279 (1962)
Govindachari et al., Helv. Chim. Acta, 45, 1146 (1962)
Govindachari et al., ibid, 46, 433, 572 (1963)
Battersby, Gregory.,J. Chern. Soc., 22 (1963)
kopsine Preparation Products And Raw materials
Raw materials
Preparation Products
kopsine
3-Hydroxy-22-oxokopsan-1-carboxylic acid methyl ester
6H,13aH-3a,5a-Ethano-5,11-methano-1H-indolizino[8,1-cd]carbazole-6-carboxylic acid, 2,3,4,5,11,12-hexahydro-5-hydroxy-14-oxo-, methyl ester, (3aR,5S,5aS,10bR,11R,13aS)- (9CI)
559-48-8