(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM
![(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM Structure](StructureFile/ChemBookStructure1/GIF/CB2176642.gif)
- CAS No.
- 1021868-76-7
- Chemical Name:
- (+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM
- Synonyms
- CR 1409 SODIUM;LORGLUMIDE SODIUM;CR-1409 sodium salt;LORGLUMIDE SODIUM SALT;sodium:4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoate;(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM;(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM
- CBNumber:
- CB2176642
- Molecular Formula:
- C22H33Cl2N2NaO4
- Molecular Weight:
- 483.41
- MDL Number:
- MFCD00083183
- MOL File:
- Mol file
(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L109 | Lorglumide sodium salt solid | 1021868-76-7 | 50mg | $192 | 2024-03-01 | Buy |
| Sigma-Aldrich | L109 | Lorglumide sodium salt solid | 1021868-76-7 | 250mg | $712 | 2023-06-20 | Buy |
| Cayman Chemical | 17555 | Lorglumide (sodium salt) ≥98% | 1021868-76-7 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17555 | Lorglumide (sodium salt) ≥98% | 1021868-76-7 | 10mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 17555 | Lorglumide (sodium salt) ≥98% | 1021868-76-7 | 25mg | $86 | 2024-03-01 | Buy |
(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM Chemical Properties,Uses,Production
Uses
Lorglumide sodium salt has been used as a cck-a (cholecystokinin A) receptor antagonist for peptide determination in rat islet cells. It has been used as a CCK1 inhibitor to check the effect of cck1 (cck-a) and cck2 (cck-b) receptors on cerulein-induced upregulation of egr-1 (early growth response 1) expression in rat pancreatic acinar cells.
Biological Activity
lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the cck-a receptor [1][2][3][4] .cholecystokinin (cck) is a peptide hormone that plays important roles in the physiological regulation of pancreatic enzyme secretion, induction of pancreatic growth, smooth muscle contraction in the gall bladder and stomach, and modulation of feeding and behavior [1][2][3].lorglumide (cr1409) is the first nonpeptidic, selective and potent inhibitor of the cck-a receptor. lorglumide inhibited cck a receptor and cck b receptor with ic50 values of 50 nm and 3 μm, respectively [4]. in the guinea-pig isolated ileum, lorglumide (0.06-2.1 μm) antagonized longitudinal muscle responses to ceruletide (a cck-related decapeptide) and cck-octapeptide (cck-8) in a concentration dependent and competitive manner. lorglumide (0.2-0.4 μm) also blocked contractions of the circular muscle induced by ceruletide [2].in mice, cr1409 completely abolished the trophic effects of exogenous cck and significantly inhibited the effects of chronic camostate feeding. cr1409 reduced pancreatic weight, dna and protein content [3].
Biochem/physiol Actions
Potent and selective non-peptide cholecystokinin (CCKA) receptor antagonist; orally active.
References
[1]. makovec f, peris w, revel l, et al. structure-antigastrin activity relationships of new (r)-4-benzamido-5-oxopentanoic acid derivatives. j med chem. 1992 jan;35(1):28-38.
[2]. barthó l, holzer p, lembeck f, et al. evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestine. br j pharmacol. 1987 apr;90(4):753-61.
[3]. niederau c, liddle ra, williams ja, et al. pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice. gut. 1987;28 suppl:63-9.
[4]. scarpignato c, varga g, dobronyi i, et al. effect of a new potent cck antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat. br j pharmacol. 1989 mar;96(3):661-9.
(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
(+/-)-4-([3,4-DICHLOROBENZOYL]AMINO)-5-(DIPENTYLAMINO)-5-OXOPENTANOIC ACID SODIUM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |