HUMAN PAI-1
- CAS No.
- 140208-23-7
- Chemical Name:
- HUMAN PAI-1
- Synonyms
- PAIE;PLANH1;Serpine 1;HUMAN PAI-1;PAI-1, MUTANT;Serpin E1 PAI-1;PAI-1, MUTANT, HUMAN;Human SERPINE1 Protein, His Tag;HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-1;Recombinant Mouse Serpine1 Protein, His Tag
- CBNumber:
- CB2231028
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01094930
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
| WGK Germany | 2 |
| HS Code | 3504009000 |
HUMAN PAI-1 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A8111 | Plasminogen activator inhibitor 1 (PAI-1) human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 140208-23-7 | 25μg | $278 | 2024-03-01 | Buy |
| Sigma-Aldrich | 528208 | Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors ap | 50μg | $373 | 2024-03-01 | Buy | |
| Sigma-Aldrich | A8111 | Plasminogen activator inhibitor 1 (PAI-1) human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 140208-23-7 | 25ug | $217 | 2021-12-16 | Buy |
| Usbiological | 491480 | SERPINE1 | 140208-23-7 | 100ul | $499 | 2021-12-16 | Buy |
| Usbiological | 133188 | SERPINE1 | 140208-23-7 | 100ug | $539 | 2021-12-16 | Buy |
HUMAN PAI-1 Chemical Properties,Uses,Production
Uses
Plasminogen activator inhibitor 1 (PAI-1) human has been used:
- as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes
- to block plasmin activation in mice infected with C. albicans hyphae
- to test its effect on neurite growth in neurons
General Description
Plasminogen activator inhibitor 1 (PAI-1) or serine protease inhibitor E1 (SERPINE1) gene is mapped to human chromosome 7q22.1. PAI-1 is produced in hepatocytes, endothelial cells, smooth muscle cells, megakaryocytes, and adipocytes.
Biochem/physiol Actions
Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.
HUMAN PAI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN PAI-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10351 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Biolab Reagents | 027-65279366 18162686757 | products@biolabreagent.com | China | 9818 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |
| Energy Chemical | 58 |
| Biolab Reagents | 58 |
| United States Biological | 58 |