NSC-12155
- CAS No.
- Chemical Name:
- NSC-12155
- Synonyms
- NSC-12155;Aminokinuride;Surfen hydrate;Aminoquincarbamide;N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea;N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea;1,3-Bis(2-methyl-4-aminoquinoline-6-yl)urea;1,3-Bis(4-amino-2-methyl-6-quinolyl)urea hydrate;(bis-2-methyl-4-amino-quinolyl-6-carbamide hydrate
- CBNumber:
- CB22378200
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD17215963
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard statements | H413 |
|---|---|
| WGK Germany | 3 |
NSC-12155 price More Price(2)
NSC-12155 Chemical Properties,Uses,Production
Uses
Surfen hydrate may be used as an antagonist to heparin.
Surfen hydrate has been used in the inhibition of multiple voltage-gated calcium channels in human embryonic kidney cells.
Biochem/physiol Actions
Surfen is a heparan sulfate antagonist, originally developed in the late thirties as an excipient for the production of depot insulin. Heparan sulfate (HS) is structurally related to heparin but contains fewer sulfate groups per disaccharide, and it exists almost exclusively attached to protein cores of proteoglycans, which cells either display on the plasma membrane or secrete into the extracellular matrix. Surfen binds to the chains of glycosaminoglycan (GAG)/HS and prevents binding of the enzymes and proteins thus act as HS antagonist. Surfen is more potent than protamine, a clinically used heparin antagonist.
NSC-12155 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC-12155 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |