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MF-63

MF-63 Structure
MF-63 structure
CAS No.
892549-43-8
Chemical Name:
MF-63
Synonyms
MF-63;CS-2773;MF 63; MF-63;2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile;1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
CBNumber:
CB22512521
Molecular Formula:
C23H11ClN4
Molecular Weight:
378.81
MDL Number:
MFCD18384972
MOL File:
892549-43-8.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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MF-63 Properties

Boiling point 709.7±70.0 °C(Predicted)
Density 1.49
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka 11.34±0.30(Predicted)
FDA UNII 7TU641M876

MF-63 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13217 MF63 ≥98% 892549-43-8 1mg $34 2024-03-01 Buy
Cayman Chemical 13217 MF63 ≥98% 892549-43-8 5mg $100 2024-03-01 Buy
Cayman Chemical 13217 MF63 ≥98% 892549-43-8 10mg $183 2024-03-01 Buy
Cayman Chemical 13217 MF63 ≥98% 892549-43-8 25mg $371 2024-03-01 Buy
Usbiological 456183 MF 63 892549-43-8 5mg $368 2021-12-16 Buy
Product number Packaging Price Buy
13217 1mg $34 Buy
13217 5mg $100 Buy
13217 10mg $183 Buy
13217 25mg $371 Buy
456183 5mg $368 Buy

MF-63 Chemical Properties,Uses,Production

Description

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC50 = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach.

Uses

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

in vitro

mf63 was found to be significantly more potent than those previously reported mpges-1 inhibitors with an intrinsic inhibitory potency on the recombinant human mpges-1 enzyme. furthermore, mf63 showed a pge2 whole cell inhibition in a549 cells and a human whole blood activity [1].

in vivo

in rodent species, mf63 inhibited guinea pig mpges-1 strongly but not the mouse or rat enzyme. when tested in the guinea pig and a knock-in (ki) mouse expressing human mpges-1, mf63 suppressed the synthesis of pge2 selectively, but not other prostaglandins that were inhibitable by nonsteroidal anti-inflammatory drugs (nsaid), yet remaided nsaid-like efficacy at inhibiting lipopolysaccharide-induced hyperalgesia, pyresis, and iodoacetate-induced osteoarthritic pain. additionally, mf63 did not cause nsaid-like gastrointestinal toxic effects, such as mucosal erosions or leakage in the ki mice or nonhuman primates, although mf63 markedly inhibited pge2 synthesis in the ki mouse stomach [1].

IC 50

0.9 and 1.3 nm for pig mpges-1 and human mpges-1

References

[1] xu d,rowland se,clark p,giroux a,cté b,guiral s,salem m,ducharme y,friesen rw,méthot n,mancini j,audoly l,riendeau d. mf63 [2-(6-chloro-1h-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin e synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. j pharmacol exp ther.2008 sep;326(3):754-63.

MF-63 Preparation Products And Raw materials

Raw materials

Preparation Products

MF-63 Suppliers

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6010 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
MF-63 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic MF 63; MF-63 CS-2773 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)- 2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile 892549-43-8 C23H11ClN4