ChemicalBook >> CAS DataBase List >>PF 184
PF 184
- CAS No.
- 1187460-81-6
- Chemical Name:
- PF 184
- Synonyms
- PF 184;8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide;1H-Benz[g]indazole-3-carboxamide, 8-[[[2-[3,4-bis(hydroxymethyl)-3,4-dimethyl-1-pyrrolidinyl]-5-chloro-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
- CBNumber:
- CB22535689
- Molecular Formula:
- C32H32ClFN6O4
- Molecular Weight:
- 619.09
- MDL Number:
- MFCD17166976
- MOL File:
- 1187460-81-6.mol
Last updated:2025-07-21 13:20:27
PF 184 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4238 | PF184 ≥98%(HPLC) | 1187460-81-6 | 10 | $331 | 2021-12-16 | Buy |
| TRC | P293750 | PF184 | 1187460-81-6 | 1mg | $165 | 2021-12-16 | Buy |
| Usbiological | 019312 | PF 184 | 1187460-81-6 | 10mg | $502 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010308 | 8-[[[5-CHLORO-2-[3,4-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-1-PYRROLIDINYL]-4-PYRIDINYL]CARBONYL]AMINO]-1-(4-FLUOROPHENYL)-4,5-DIHYDRO-1H-BENZ[G]INDAZOLE-3-CARBOXAMIDE 95.00% | 1187460-81-6 | 10MG | $716.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010308 | 8-[[[5-CHLORO-2-[3,4-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-1-PYRROLIDINYL]-4-PYRIDINYL]CARBONYL]AMINO]-1-(4-FLUOROPHENYL)-4,5-DIHYDRO-1H-BENZ[G]INDAZOLE-3-CARBOXAMIDE 95.00% | 1187460-81-6 | 25MG | $779.63 | 2021-12-16 | Buy |
PF 184 Chemical Properties,Uses,Production
Uses
PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.
in vivo
(Rac)-PF-184 (0.3-2.5 mg; i.t.; once) blocks neutrophil infiltration and BAL cell cytokine production[1].
| Animal Model: | Fasted male Sprague-Dawley rats (350 g) placed into a chamber connected to a large volume nebulizer filled with 20 ml of 1 mg/mL solution of LPS[1] |
| Dosage: | 0.3-2.5 mg |
| Administration: | Nano suspension and administered intratracheally in a volume of 100 μL, 60 min before aerosolized LPS |
| Result: | Resulted in a comparable attenuation of total cell and PMN cell infiltration 4 h after LPS exposure. Dose-dependently inhibited cell infiltration with EC50 values of 1 mg. Dose-dependently suppressed BAL fluid TNF- and PGE2 levels comparable with cell infiltration. Inhibited p65 translocation. Showed long-lasting activity. |
IC 50
IKK-2: 37 nM (IC50)
storage
Store at +4°C
PF 184 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24982 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5686 | 58 |
PF 184
8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide
1H-Benz[g]indazole-3-carboxamide, 8-[[[2-[3,4-bis(hydroxymethyl)-3,4-dimethyl-1-pyrrolidinyl]-5-chloro-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
1187460-81-6
C32H32ClFN6O4
Amines
Aromatics
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pfizer Compounds
Pharmaceuticals
