| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PF 184
CAS:1187460-81-6
Package:100Mg,10Mg
|
| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:PF 184;8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide;
CAS:1187460-81-6
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
- PF-184
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- $3100.00 / 100mg
-
2025-10-27
- CAS:
- Min. Order:
- Purity:
- Supply Ability: 10g
- PF 184
-
- $987.00 / 10mg
-
2024-10-24
- CAS:1187460-81-6
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | PF 184 Chemical Properties |
| Boiling point | 790.6±60.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | pka | 10.20±0.20(Predicted) |
| | PF 184 Usage And Synthesis |
| Uses | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. | | in vivo | (Rac)-PF-184 (0.3-2.5 mg; i.t.; once) blocks neutrophil infiltration and BAL cell cytokine production[1]. | Animal Model: | Fasted male Sprague-Dawley rats (350 g) placed into a chamber connected to a large volume nebulizer filled with 20 ml of 1 mg/mL solution of LPS[1] | | Dosage: | 0.3-2.5 mg | | Administration: | Nano suspension and administered intratracheally in a volume of 100 μL, 60 min before aerosolized LPS | | Result: | Resulted in a comparable attenuation of total cell and PMN cell infiltration 4 h after LPS exposure. Dose-dependently inhibited cell infiltration with EC50 values of 1 mg. Dose-dependently suppressed BAL fluid TNF- and PGE2 levels comparable with cell infiltration. Inhibited p65 translocation. Showed long-lasting activity. |
| | IC 50 | IKK-2: 37 nM (IC50) | | storage | Store at +4°C |
| | PF 184 Preparation Products And Raw materials |
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