BAX INHIBITOR PEPTIDE P5
- CAS No.
- 579492-83-4
- Chemical Name:
- BAX INHIBITOR PEPTIDE P5
- Synonyms
- BAX INHIBITOR PEPTIDE P5;L-Glutamic acid, L-prolyl-L-methionyl-L-leucyl-L-lysyl-
- CBNumber:
- CB2262796
- Molecular Formula:
- C27H48N6O8S
- Molecular Weight:
- 616.77
- MDL Number:
- MFCD26792550
- MOL File:
- 579492-83-4.mol
BAX INHIBITOR PEPTIDE P5 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ApexBio Technology | A4460 | BaxinhibitorpeptideP5 | 579492-83-4 | 5mg | $120 | 2021-12-16 | Buy |
ApexBio Technology | A4460 | BaxinhibitorpeptideP5 | 579492-83-4 | 10mg | $180 | 2021-12-16 | Buy |
ApexBio Technology | A4460 | BaxinhibitorpeptideP5 | 579492-83-4 | 100mg | $1080 | 2021-12-16 | Buy |
BAX INHIBITOR PEPTIDE P5 Chemical Properties,Uses,Production
Uses
Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM).
Biological Activity
bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1].
References
[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
BAX INHIBITOR PEPTIDE P5 Preparation Products And Raw materials
Raw materials
Preparation Products
BAX INHIBITOR PEPTIDE P5 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
AdooQ BioScience, LLC | 58 |
Absin Bioscience Inc. | 58 |
MedBioPharmaceutical Technology Inc | 58 |
ApexBio Technology | 58 |