ChemicalBook >> CAS DataBase List >>N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- CAS No.
- 31750-48-8
- Chemical Name:
- N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- Synonyms
- ici55,548;desmethyltamoxifen;n-desmethyltamoxifen;Tamoxifen EP Impurity F;N-DESMETHYL TAMOXIFEN HCL;tamoxifen citrate impurity F;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
- CBNumber:
- CB2267847
- Molecular Formula:
- C25H27NO
- Molecular Weight:
- 357.49
- MDL Number:
- MFCD03423594
- MOL File:
- 31750-48-8.mol
Last updated:2023-05-21 10:59:17
| Boiling point | 485.8±33.0 °C(Predicted) |
|---|---|
| Density | 1.047±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM) |
| pka | 9.38±0.10(Predicted) |
| Water Solubility | Water: Insoluble |
| FDA UNII | OOJ759O35C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H350-H302-H372-H360 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501 |
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | D3220-90M | N-Desmethyltamoxifen, Hydrochloride | 31750-48-8 | 5mg | $460 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 34558 | N-Desmethyltamoxifen HCl | 31750-48-8 | 5mg | $1440 | 2021-12-16 | Buy |
| Acrotein | DM-3492 | 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamineHCl 97% | 31750-48-8 | 1g | $220 | 2021-12-16 | Buy |
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Chemical Properties,Uses,Production
Definition
ChEBI: N-Desmethyltamoxifen is a stilbenoid.
Biological Activity
N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.
in vitro
N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
| Cell Line: | MCF 7 human mammary carcinoma cells |
| Concentration: | 1.5, 2.5, 5, 7.5, 10 μM | td>
| Incubation Time: | 114 hours |
| Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |
target
| PKC
| Estrogen Receptor
| < /table>
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6943 | 65 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
31750-48-8(N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE)Related Search:
(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE
N-DESMETHYL TAMOXIFEN HCL
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
desmethyltamoxifen
ici55,548
n-desmethyltamoxifen
Tamoxifen EP Impurity F
2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
(Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
tamoxifen citrate impurity F
2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methyl-ethanamine
31750-48-8