MK-8931
- CAS No.
- 1286770-55-5
- Chemical Name:
- MK-8931
- Synonyms
- CS-2556;SCH900931;SCH-900931;SCH 900931;MK-8931-009;Verubecestat;MK-8931(Verubecestat);Verubecestat free base;Verubecestat (MK-8931);MK8931;MK 8931;MK-8931
- CBNumber:
- CB22756736
- Molecular Formula:
- C17H17F2N5O3S
- Molecular Weight:
- 409.41
- MDL Number:
- MFCD28963974
- MOL File:
- 1286770-55-5.mol
- MSDS File:
- SDS
| Melting point | 160-162oC |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.92±0.70(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | J1I0P6WT7T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MK-8931 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21115 | Verubecestat ≥98% | 1286770-55-5 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 21115 | Verubecestat ≥98% | 1286770-55-5 | 5mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 21115 | Verubecestat ≥98% | 1286770-55-5 | 10mg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 21115 | Verubecestat ≥98% | 1286770-55-5 | 25mg | $246 | 2024-03-01 | Buy |
| TRC | V128850 | Verubecestat | 1286770-55-5 | 25mg | $235 | 2021-12-16 | Buy |
MK-8931 Chemical Properties,Uses,Production
Uses
Verubecestat is used in a β-site amyloid precursor protein cleaving enzyme I inhibitor of treatment of alzheimer’s disease.
Biological Activity
ki: 2.2 and 3.4 nm for human and mouse bace1, respectivelyverubecestat (mk-8931) is a bace1 inhibitor.β-amyloid (aβ) peptides are regarded to be involved in the etiology of ad. bace1 is required for the aβ production, and bace1 inhibition is therefore an promising target for the ad treatment.
in vitro
verubecestat has been identified as a potent inhibitor of both human and mouse bace1 and verubecestat could also inhibit the production of ab40, ab42, and sappb in human cells with similar potency. verubecestat was also found to be a potent inhibitor of purified human bace2. moreover, verubecestat was essentially inactive with over 45,000-fold selectivity in the purified human aspartyl proteases cathepsin d, cathepsin e, and pepsin and had a very weak inhibitor of purified human renin with 15,000-fold selectivity. in addition, verubecestat was also found to have minimal or no activity against various tested receptors, ion channels, transporters, as well as enzymes [1].
in vivo
verubecestat could reduce plasma, cerebrospinal fluid, and brain concentrations of aβ40, aβ42, and sappβ after acute and chronic administration to both rats and monkeys. moreover, the chronic treatment of rats and monkeys with verubecestat at exposures >40-fold higher than those tested in
storage
Store at -20°C
References
[1] kennedy me et al. the bace1 inhibitor verubecestat (mk-8931) reduces cns β-amyloid in animal models and in alzheimer's disease patients. sci transl med.2016 nov 2;8(363):363ra150.
MK-8931 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12975 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
