IRL-2500
- CAS No.
- 169545-27-1
- Chemical Name:
- IRL-2500
- Synonyms
- IRL-2500;IRL 2500, 10 mM in DMSO;N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN;L-Tryptophan, 3-[1,1'-biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-;((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan
- CBNumber:
- CB2281962
- Molecular Formula:
- C36H35N3O4
- Molecular Weight:
- 573.68
- MDL Number:
- MFCD00948945
- MOL File:
- 169545-27-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| IRL-2500 ≥99%(HPLC) | 1838 | 10 | $280 |
| IRL-2500 | I749008 | 10mg | $255 |
| IRL-2500 | 255524 | 10mg | $545 |
| IRL-2500 95.00% | API0008078 | 1G | $754.95 |
| IRL2500 >99.0% | CS-0027938 | 10mg | $795 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
IRL-2500 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1838 | IRL-2500 ≥99%(HPLC) | 169545-27-1 | 10 | $280 | 2021-12-16 | Buy |
| TRC | I749008 | IRL-2500 | 169545-27-1 | 10mg | $255 | 2021-12-16 | Buy |
| Usbiological | 255524 | IRL-2500 | 169545-27-1 | 10mg | $545 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008078 | IRL-2500 95.00% | 169545-27-1 | 1G | $754.95 | 2021-12-16 | Buy |
| ChemScene | CS-0027938 | IRL2500 >99.0% | 169545-27-1 | 10mg | $795 | 2021-12-16 | Buy |
IRL-2500 Chemical Properties,Uses,Production
Uses
IRL 2500 is a potent endothelin ETB selective antagonist.
Biological Activity
Potent endothelin receptor antagonist; shows some selectivity for ET B receptors (IC 50 values are 1.3 and 94 nM for ET B and ET A receptors respectively). Inhibits ET B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .
in vivo
IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1]. IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].
IC 50
ETB: 1.3 nM (IC50); ETA: 94 nM (IC50)
storage
Desiccate at RT
IRL-2500 Preparation Products And Raw materials
Raw materials
Preparation Products
IRL-2500 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9550 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16027 | 58 |
