2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- CAS No.
- 1609394-10-6
- Chemical Name:
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- Synonyms
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine;Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-;EOS-61512;Deucravacitinib Impurity 8;BMS-986165 Related Compound 3;2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline;2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline;2-Methoxy-3-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenylamine
- CBNumber:
- CB23122644
- Molecular Formula:
- C10H12N4O
- Molecular Weight:
- 204.23
- MDL Number:
- MFCD30489435
- MOL File:
- 1609394-10-6.mol
| Boiling point | 437.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| solubility | DMSO (Slightly) |
| pka | 3.45±0.10(Predicted) |
| form | Solid |
| color | Pale Orange to Brown |
| InChI | InChI=1S/C10H12N4O/c1-14-6-12-10(13-14)7-4-3-5-8(11)9(7)15-2/h3-6H,11H2,1-2H3 |
| InChIKey | FIAZRZSVFOMYSD-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=CC(C2N=CN(C)N=2)=C1OC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P261-P280-P301+P310-P311 |
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Chemical Properties,Uses,Production
Chemical Properties
white solid
Uses
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases.
Synthesis
To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg) were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C. 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Preparation Products And Raw materials
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 228 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 222 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Unibest Industrial Co.,Ltd. | +86-8657427855777 +86-18758850676 | info@unibestcn.com | China | 344 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
View Lastest Price from 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
|
US $0.00 / kg | 1kg | 98% | 500KG | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2024-04-10 | 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
|
US $0.00 / kg | 1kg | 98% | 50kg | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2023-11-01 | 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
|
US $0.00-0.00 / kg | 1kg | 99.0% | 20 tons | Hangzhou ICH Biofarm Co., Ltd |
-
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
- US $0.00-0.00 / kg
- 99.0%
- Hangzhou ICH Biofarm Co., Ltd