SP 141
- CAS No.
- 1253491-42-7
- Chemical Name:
- SP 141
- Synonyms
- SP 141;SP 141;SP141;;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
- CBNumber:
- CB23146385
- Molecular Formula:
- C22H16N2O
- Molecular Weight:
- 324.38
- MDL Number:
- MFCD29059920
- MOL File:
- 1253491-42-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
SP 141 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17003 | SP 141 ≥98% | 1253491-42-7 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 1253491-42-7 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 1253491-42-7 | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17003 | SP 141 ≥98% | 1253491-42-7 | 50mg | $849 | 2024-03-01 | Buy |
| Tocris | 5332 | SP141 ≥98%(HPLC) | 1253491-42-7 | 50 | $870 | 2021-12-16 | Buy |
SP 141 Chemical Properties,Uses,Production
Description
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.
Uses
SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines, inhibiting xenograft tumor growth in vivo.
storage
Store at +4°C
References
[1]. vassilev lt, vu bt, graves b, et al. in vivo activation of the p53 pathway by small-molecule antagonists of mdm2. science. 2004 feb 6;303(5659):844-8.
[2]. wang w, qin jj, voruganti s, et al. the pyrido[b]indole mdm2 inhibitor sp-141 exerts potent therapeutic effects in breast cancer models. nat commun. 2014 oct 1;5:5086.
[3]. wang w, qin jj, voruganti s, et al. identification of a new class of mdm2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. gastroenterology. 2014 oct;147(4):893-902.e2.
[4]. nag s, qin jj, voruganti s, et al. development and validation of a rapid hplc method for quantitation of sp-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. biomed chromatogr. 2015 may;29(5):654-63.
SP 141 Preparation Products And Raw materials
Raw materials
Preparation Products
SP 141 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 | order@changyanchem.com | China | 5008 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Taizhou Crene Biotechnology Co. Ltd. | 0576-88813233 13396860566 | sales@pharm-intermediates.com | China | 2013 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |