2'2'-cGAMP
- CAS No.
- 1465774-27-9
- Chemical Name:
- 2'2'-cGAMP
- Synonyms
- 2’2’-cGAMP;2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'2'-cGAMP (sodium salt);c[A(2′,,5′,)pG(2′,,5′,)p];2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
- CBNumber:
- CB23311738
- Molecular Formula:
- C20H24N10O13P2
- Molecular Weight:
- 674.411
- MDL Number:
- MOL File:
- 1465774-27-9.mol
| Product description | Number | Pack Size | Price |
| 2’2’-cGAMP (sodium salt) | 22419 | 500μg | $422 |
| 2’2’-cGAMP (sodium salt) | 22419 | 1mg | $714 |
2'2'-cGAMP price More Price(2)
2'2'-cGAMP Chemical Properties,Uses,Production
Description
2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).
Uses
2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs[1].
References
[1] Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013;51(2):226-235. DOI:10.1016/j.molcel.2013.05.022
2'2'-cGAMP Preparation Products And Raw materials
Raw materials
Preparation Products
2'2'-cGAMP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5929 | 58 |
| Shanghai Fine Biotech Co.，Ltd | 18221172427 | sale@fine-biotech.com | China | 2745 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 6174 | 58 |
View Lastest Price from 2'2'-cGAMP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-01 | 2'2'-cGAMP (sodium salt)
1465774-27-9
|
US $1780.00 / mg | 10g | TargetMol Chemicals Inc. |
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- 2'2'-cGAMP (sodium salt)
1465774-27-9
- US $1780.00 / mg
- TargetMol Chemicals Inc.
