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Cilofexor

CAS No.
1418274-28-8
Chemical Name:
Cilofexor
Synonyms
CS-2761;Cilofexor;Cilofexor (GS-9674);GS-9674;GS9674;CILOFEXOR;2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid;GS9674,Inhibitor,inhibit,NR1H4,FXR,Cilofexor,PSC,GS 9674,oral,NASH,GS-9674,antifibrotic,nonsteroidal,anti-inflammatory,Autophagy,safety;4-Pyridinecarboxylic acid, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-;2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid
CBNumber:
CB23956597
Molecular Formula:
C28H22Cl3N3O5
Molecular Weight:
586.85
MDL Number:
MFCD31731099
MOL File:
1418274-28-8.mol
Last updated:2023-05-21 10:59:17

Cilofexor Properties

Boiling point 855.5±65.0 °C(Predicted)
Density 1.538±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:32.5(Max Conc. mg/mL);55.38(Max Conc. mM)
form A crystalline solid
pka 2.10±0.10(Predicted)
FDA UNII YUN2306954

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Cilofexor price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25747 Cilofexor ≥98% 1418274-28-8 1mg $39 2024-03-01 Buy
Cayman Chemical 25747 Cilofexor ≥98% 1418274-28-8 5mg $202 2024-03-01 Buy
Cayman Chemical 25747 Cilofexor ≥98% 1418274-28-8 10mg $363 2024-03-01 Buy
Cayman Chemical 25747 Cilofexor ≥98% 1418274-28-8 25mg $745 2024-03-01 Buy
ChemScene CS-0039260 Cilofexor 99.82% 1418274-28-8 50mg $840 2021-12-16 Buy
Product number Packaging Price Buy
25747 1mg $39 Buy
25747 5mg $202 Buy
25747 10mg $363 Buy
25747 25mg $745 Buy
CS-0039260 50mg $840 Buy

Cilofexor Chemical Properties,Uses,Production

Description

Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). It has FXR agonist activity in a mammalian one hybrid (M1H) assay (EC50 = ≥100 nM).

1418274-31-3
1418274-28-8
Synthesis of Cilofexor from 4-((4-Bromo-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-isoxazole

Cilofexor Preparation Products And Raw materials

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Chemia Biotechnology(Shanghai) Co., Ltd
+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58

View Lastest Price from Cilofexor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cilofexor pictures 2020-01-03 Cilofexor
1418274-28-8
US $9.80 / KG 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co
  • Cilofexor pictures
  • Cilofexor
    1418274-28-8
  • US $9.80 / KG
  • 97%-99%
  • Career Henan Chemical Co
Cilofexor Cilofexor (GS-9674) 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid GS-9674;GS9674;CILOFEXOR CS-2761 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid 4-Pyridinecarboxylic acid, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]- GS9674,Inhibitor,inhibit,NR1H4,FXR,Cilofexor,PSC,GS 9674,oral,NASH,GS-9674,antifibrotic,nonsteroidal,anti-inflammatory,Autophagy,safety 1418274-28-8 C28H22Cl3N3O5 API