Ac-IETD-CHO (trifluoroacetate salt)
- CAS No.
- Chemical Name:
- Ac-IETD-CHO (trifluoroacetate salt)
- Synonyms
- Ac-IETD-CHO (trifluoroacetate salt)
- CBNumber:
- CB24814249
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Ac-IETD-CHO (trifluoroacetate salt) price More Price(2)
Ac-IETD-CHO (trifluoroacetate salt) Chemical Properties,Uses,Production
Description
Ac-IETD-CHO is an inhibitor of caspase-8 (IC50 = 5 nM).1 It inhibits fluticasone propionate-induced increases in apoptosis in peripheral blood T-cells isolated from patients with asthma when used at a concentration 60 μM.2 Ac-IETD-CHO (10 mg/kg) inhibits increases in hepatic caspase-3 activity, DNA fragmentation, cytosolic cytochrome c levels, and proteolytic processing of caspase-3, -8, and -9 proenzymes in a mouse model of Fas-induced apoptosis and liver failure.3WARNING This product is not for human or veterinary use.
References
[1] GARY K. SMITH . Expression, Preparation, and High-Throughput Screening of Caspase-8: Discovery of Redox-Based and Steroid Diacid Inhibition[J]. Archives of biochemistry and biophysics, 2002, 399 2: Pages 195-205. DOI: 10.1006/abbi.2002.2757
[2] ELISABETTA PACE MD , PHD. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma[J]. Journal of Allergy and Clinical Immunology, 2004, 114 5: Pages 1216-1223. DOI: 10.1016/j.jaci.2004.07.052
[3] M L BAJT. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8.[J]. Toxicological Sciences, 2000, 58 1: 109-117. DOI: 10.1093/toxsci/58.1.109
Ac-IETD-CHO (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Ac-IETD-CHO (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Guangzhou Qiansheng Biotechnology Co., Ltd. | 14748676110 | CHINA | 112 | 58 |
